Cell Division Cycle Protein 42 (CDC42)

[Edit]

CDC42Hs; G25K; G25K GTP-binding protein

Cell Division Cycle Protein 42 (CDC42)
CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression.
This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE614Hu01 Recombinant Cell Division Cycle Protein 42 (CDC42) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE614Hu21 Monoclonal Antibody to Cell Division Cycle Protein 42 (CDC42) WB; IHC; ICC; IP.
PAE614Hu01 Polyclonal Antibody to Cell Division Cycle Protein 42 (CDC42) WB; IHC; ICC; IP.
Assay Kits SEE614Hu ELISA Kit for Cell Division Cycle Protein 42 (CDC42) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE614Mu01 Recombinant Cell Division Cycle Protein 42 (CDC42) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 42 (CDC42) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 42 (CDC42) Polyclonal Antibody Customized Service Offer
Assay Kits SEE614Mu ELISA Kit for Cell Division Cycle Protein 42 (CDC42) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 42 (CDC42) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 42 (CDC42) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 42 (CDC42) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 42 (CDC42) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 42 (CDC42) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42."Mol. Cell. Biol. 10:5977-5982(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42."Proc. Natl. Acad. Sci. U.S.A. 87:9853-9857(1990) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (DEC-2008) to UniProtKB
  6. "Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins."Biochemistry 32:5711-5717(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain."Biochem. Biophys. Res. Commun. 160:25-32(1989) [PubMed] [Europe PMC] [Abstract]
  8. "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins."Mol. Cell. Biol. 19:6585-6597(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas."Nat. Cell Biol. 1:507-513(1999) [PubMed] [Europe PMC] [Abstract]
  10. "SPECs, small binding proteins for Cdc42."J. Biol. Chem. 275:22650-22656(2000) [PubMed] [Europe PMC] [Abstract]
  11. "The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1."J. Cell Sci. 113:3267-3275(2000) [PubMed] [Europe PMC] [Abstract]
  12. "IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling."Nature 408:732-735(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C."Genes Cells 6:107-119(2001) [PubMed] [Europe PMC] [Abstract]
  14. "The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading."J. Cell Biol. 156:377-387(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins."Nat. Cell Biol. 4:639-647(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase."J. Biol. Chem. 278:49293-49300(2003) [PubMed] [Europe PMC] [Abstract]
  17. "The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling."Mol. Cell. Biol. 23:2151-2161(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs."Mol. Biol. Cell 15:2205-2217(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis."J. Cell Biol. 168:221-232(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas."J. Biol. Chem. 281:37527-37535(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease."Nat. Med. 14:1370-1376(2008) [PubMed] [Europe PMC] [Abstract]
  22. "The fic domain: regulation of cell signaling by adenylylation."Mol. Cell 34:93-103(2009) [PubMed] [Europe PMC] [Abstract]
  23. "AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling."Science 323:269-272(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."J. Proteome Res. 9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  26. "The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42."Br. J. Cancer 104:324-331(2011) [PubMed] [Europe PMC] [Abstract]
  27. "ARHGDIA: a novel gene implicated in nephrotic syndrome."J. Med. Genet. 50:330-338(2013) [PubMed] [Europe PMC] [Abstract]
  28. "Definition of the switch surface in the solution structure of Cdc42Hs."Biochemistry 36:8755-8766(1997) [PubMed] [Europe PMC] [Abstract]
  29. "Identification of the binding surface on Cdc42Hs for p21-activated kinase."Biochemistry 37:14030-14037(1998) [PubMed] [Europe PMC] [Abstract]
  30. "Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP."Nature 388:693-697(1997) [PubMed] [Europe PMC] [Abstract]
  31. "Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal."Protein Sci. 8:778-787(1999) [PubMed] [Europe PMC] [Abstract]
  32. "The structure determination of CDC42Hs and GDP complex."Submitted (JUN-1997) to the PDB data bank
  33. "Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor."Science 325:1398-1402(2009) [PubMed] [Europe PMC] [Abstract]
  34. "Structural basis of Fic-mediated adenylylation."Nat. Struct. Mol. Biol. 17:1004-1010(2010) [PubMed] [Europe PMC] [Abstract]