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B-Cell CLL/Lymphoma 6 (Bcl6)

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BCL5; BCL6A; LAZ3; ZBTB27; ZNF51; Zinc Finger Protein 51; Zinc finger and BTB domain-containing protein 27

B-Cell CLL/Lymphoma 6 (Bcl6)
CCC E586
HGNC 1001
MGI 107187
PubMed 20124477
RGD 1309345
UniProt P41182
Wiki BCL6
B-cell lymphoma 6 protein is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent Interleukin 4 (IL-4) responses of B cells.
This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large B cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Two alternatively spliced transcript variants that encode the identical protein have been reported for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE586Hu01 Recombinant B-Cell CLL/Lymphoma 6 (Bcl6) Positive Control; Immunogen; SDS-PAGE; WB.
RPE586Hu02 Recombinant B-Cell CLL/Lymphoma 6 (Bcl6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE586Hu01 Polyclonal Antibody to B-Cell CLL/Lymphoma 6 (Bcl6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for B-Cell CLL/Lymphoma 6 (Bcl6) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell CLL/Lymphoma 6 (Bcl6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell CLL/Lymphoma 6 (Bcl6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell CLL/Lymphoma 6 (Bcl6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell CLL/Lymphoma 6 (Bcl6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell CLL/Lymphoma 6 (Bcl6) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell CLL/Lymphoma 6 (Bcl6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell CLL/Lymphoma 6 (Bcl6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell CLL/Lymphoma 6 (Bcl6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell CLL/Lymphoma 6 (Bcl6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell CLL/Lymphoma 6 (Bcl6) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell CLL/Lymphoma 6 (Bcl6) ELISA Kit Customized Service Offer
  1. "LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas."Nat. Genet. 5:66-70(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma."Science 262:747-750(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kruppel-like zinc-finger protein."Blood 83:26-32(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas."Proc. Natl. Acad. Sci. U.S.A. 90:5262-5266(1993) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor."Genes Dev. 12:1953-1961(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Nonrandom fusion of L-plastin(LCP1) and LAZ3(BCL6) genes by t(3;13)(q27;q14) chromosome translocation in two cases of B-cell non-Hodgkin lymphoma."Genes Chromosomes Cancer 26:97-105(1999) [PubMed] [Europe PMC] [Abstract]
  9. "The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma."Blood 95:2719-2721(2000) [PubMed] [Europe PMC] [Abstract]
  10. "BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control."Immunity 13:199-212(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of t(3;6)(q27;p21) breakpoints in B-cell non-Hodgkin's lymphoma and construction of the histone H4/BCL6 fusion gene, leading to altered expression of Bcl-6."Cancer Res. 62:6224-6230(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Acetylation inactivates the transcriptional repressor BCL6."Nat. Genet. 32:606-613(2002) [PubMed] [Europe PMC] [Abstract]
  13. "The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma."Oncogene 21:368-376(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers."Biochem. Biophys. Res. Commun. 300:391-396(2003) [PubMed] [Europe PMC] [Abstract]
  15. "The histone deacetylase 9 gene encodes multiple protein isoforms."J. Biol. Chem. 278:16059-16072(2003) [PubMed] [Europe PMC] [Abstract]
  16. "MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation."Cell 119:75-86(2004) [PubMed] [Europe PMC] [Abstract]
  17. "The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B-cells."Nature 432:635-639(2004) [PubMed] [Europe PMC] [Abstract]
  18. "BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells."Nat. Immunol. 6:1054-1060(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells."Exp. Cell Res. 312:1312-1322(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells."Nat. Immunol. 8:1132-1139(2007) [PubMed] [Europe PMC] [Abstract]
  21. "CtBP is an essential corepressor for BCL6 autoregulation."Mol. Cell. Biol. 28:2175-2186(2008) [PubMed] [Europe PMC] [Abstract]
  22. "BCL6 positively regulates AID and germinal center gene expression via repression of miR-155."J. Exp. Med. 209:2455-2465(2012) [PubMed] [Europe PMC] [Abstract]
  23. "FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas."Nature 481:90-93(2012) [PubMed] [Europe PMC] [Abstract]
  24. "A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters."Cell Rep. 4:578-588(2013) [PubMed] [Europe PMC] [Abstract]
  25. "Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain."Mol. Cell 12:1551-1564(2003) [PubMed] [Europe PMC] [Abstract]
  26. "Solution structure of the C2H2 type zinc finger (region 598-654) of human B-cell lymphoma 6 protein."Submitted (OCT-2007) to the PDB data bank
  27. "Structure of the wild-type human BCL6 POZ domain."Acta Crystallogr. F 64:1101-1104(2008) [PubMed] [Europe PMC] [Abstract]
  28. "Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer."Mol. Cell 29:384-391(2008) [PubMed] [Europe PMC] [Abstract]
  29. "A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo."Cancer Cell 17:400-411(2010) [PubMed] [Europe PMC] [Abstract]