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Gasdermin D (GSDMD)

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GSDMDC1; DF5L; Gasdermin Domain Containing 1

Gasdermin D (GSDMD)
CCC E529
HGNC 25697
MGI 1916396
PubMed 19051310
RGD 1307261
UniProt P57764
Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.
GSDM showed apoptotic activity upon expression in a human gastric cancer cell line. LMO1, RUNX3, and TGF-beta receptor II (TGFBR2) were coexpressed with GSDM in pit cells, and both LMO1 and RUNX3 bound to the GSDM promoter in vitro. TGF-beta (TGFB1) upregulated LMO1 and GSDM expression and induced apoptosis, and induction of apoptosis was inhibited by suppression of LMO1, RUNX3, and GSDM expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE529Hu01 Recombinant Gasdermin D (GSDMD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE529Hu01 Polyclonal Antibody to Gasdermin D (GSDMD) WB
Assay Kits SEE529Hu ELISA Kit for Gasdermin D (GSDMD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE529Mu01 Recombinant Gasdermin D (GSDMD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE529Mu01 Polyclonal Antibody to Gasdermin D (GSDMD) WB; IHC; ICC; IP.
Assay Kits SEE529Mu ELISA Kit for Gasdermin D (GSDMD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE529Ra01 Recombinant Gasdermin D (GSDMD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE529Ra01 Polyclonal Antibody to Gasdermin D (GSDMD) WB; IHC; ICC; IP.
Assay Kits SEE529Ra ELISA Kit for Gasdermin D (GSDMD) Enzyme-linked immunosorbent assay for Antigen Detection.
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