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Sodium Iodide Symporter (NIS)

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SLC5A5; Solute Carrier Family 5 Member 5; Na(+)/I(-) cotransporter

Sodium Iodide Symporter (NIS)
CCC E385
HGNC 11040
MGI 2149330
PubMed 12588808
RGD 69267
UniProt Q92911
Wiki SLC5A5
The sodium-iodide symporter (NIS) is an ion pump that actively transports iodide (I-) across the basolateral membrane into thyroid epithelial cells. The NIS a member of the sodium/solute symporter family.Active transport of iodine into the thyroid gland is an important step in the process of iodide organification and the formation of triiodothyronine (T3) and thyroxine (T4). The symporter is stimulated by TSH, thereby increasing iodine uptake and iodination of tyrosine.The pump symports two sodium ions for every iodide ion. This symporter is driven by low internal sodium concentration in the thyroid epithelial cells, via facilitated diffusion, caused by the sodium/potassium ATPase pump.This pump is the target of certain anion based inhibitors such as perchlorate, pertechnetate, and thiocyanate.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE385Hu01 Recombinant Sodium Iodide Symporter (NIS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE385Hu21 Monoclonal Antibody to Sodium Iodide Symporter (NIS) WB; IHC; ICC; IP.
PAE385Hu01 Polyclonal Antibody to Sodium Iodide Symporter (NIS) WB; IHC; ICC; IP.
Assay Kits SEE385Hu ELISA Kit for Sodium Iodide Symporter (NIS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Iodide Symporter (NIS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Iodide Symporter (NIS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Iodide Symporter (NIS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Iodide Symporter (NIS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Iodide Symporter (NIS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Iodide Symporter (NIS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Iodide Symporter (NIS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Iodide Symporter (NIS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Iodide Symporter (NIS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Iodide Symporter (NIS) ELISA Kit Customized Service Offer
  1. "Cloning of the human sodium iodide symporter."Biochem. Biophys. Res. Commun. 226:339-345(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Increased expression of the Na+/I- symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue."J. Clin. Endocrinol. Metab. 82:3331-3336(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Congenital hypothyroidism caused by a mutation in the Na(+)/I(-) symporter."Nat. Genet. 16:124-125(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Novel, missense and loss-of-function mutations in the sodium/iodide symporter gene causing iodide transport defect in three Japanese patients."J. Clin. Endocrinol. Metab. 83:3373-3376(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Congenital hypothyroidism due to mutations in the sodium/iodide symporter: identification of a nonsense mutation producing a downstream cryptic 3' splice site."J. Clin. Invest. 101:1028-1035(1998) [PubMed] [Europe PMC] [Abstract]
  8. "A novel mutation in the sodium/iodide symporter gene in the largest family with iodide transport defect."J. Clin. Endocrinol. Metab. 84:3248-3253(1999) [PubMed] [Europe PMC] [Abstract]