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Na-Cl Cotransporter (NCCT)

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SLC12A3; TSC; NCC; Solute Carrier Family 12 Member 3,Sodium/Chloride Transporters; Thiazide-sensitive sodium-chloride cotransporter; Na-Cl symporter

Na-Cl Cotransporter (NCCT)
CCC E361
HGNC 10912
MGI 108114
PubMed 19668106
RGD 3686
UniProt P55017
Wiki NCCT
SLC12A3 encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. The predicted protein sequence of 1,021 amino acids (112 kD) showed a structure common to other members of the Na-K-Cl cotransporter family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE361Hu01 Recombinant Na-Cl Cotransporter (NCCT) Positive Control; Immunogen; SDS-PAGE; WB.
RPE361Hu02 Recombinant Na-Cl Cotransporter (NCCT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE361Hu01 Polyclonal Antibody to Na-Cl Cotransporter (NCCT) WB; IHC; ICC; IP.
LAE361Hu71 Biotin-Linked Polyclonal Antibody to Na-Cl Cotransporter (NCCT) WB; IHC; ICC.
LAE361Hu81 FITC-Linked Polyclonal Antibody to Na-Cl Cotransporter (NCCT) WB; IHC; ICC; IF.
MAE361Hu21 Monoclonal Antibody to Na-Cl Cotransporter (NCCT) WB
PAE361Hu02 Polyclonal Antibody to Na-Cl Cotransporter (NCCT) WB; IHC; ICC; IP.
MAE361Hu22 Monoclonal Antibody to Na-Cl Cotransporter (NCCT) WB; IHC; ICC; IP.
MAE361Hu23 Monoclonal Antibody to Na-Cl Cotransporter (NCCT) WB; IHC; ICC; IP.
MAE361Hu24 Monoclonal Antibody to Na-Cl Cotransporter (NCCT) WB; IHC; ICC; IP.
MAE361Hu25 Monoclonal Antibody to Na-Cl Cotransporter (NCCT) WB; IHC; ICC; IP.
Assay Kits SEE361Hu ELISA Kit for Na-Cl Cotransporter (NCCT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Na-Cl Cotransporter (NCCT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Na-Cl Cotransporter (NCCT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Na-Cl Cotransporter (NCCT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Na-Cl Cotransporter (NCCT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Na-Cl Cotransporter (NCCT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Na-Cl Cotransporter (NCCT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Na-Cl Cotransporter (NCCT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Na-Cl Cotransporter (NCCT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Na-Cl Cotransporter (NCCT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Na-Cl Cotransporter (NCCT) ELISA Kit Customized Service Offer
  1. "Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter."Nat. Genet. 12:24-30(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3)."Genomics 35:486-493(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Similar Effects of all WNK3 Variants upon SLC12 Cotransporters."Am. J. Physiol. 301:C601-C608(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Novel molecular variants of the Na-Cl cotransporter gene are responsible for Gitelman syndrome."Am. J. Hum. Genet. 59:1019-1026(1996) [PubMed] [Europe PMC] [Abstract]
  7. "KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron." Nat. Genet. 44:456-460(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Association of a mutation in thiazide-sensitive Na-Cl cotransporter with familial Gitelman's syndrome."J. Clin. Endocrinol. Metab. 81:4496-4499(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Novel mutations in the thiazide-sensitive NaCl cotransporter gene in patients with Gitelman syndrome with predominant localization to the C-terminal domain."Kidney Int. 54:720-730(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Genetic variants of thiazide-sensitive NaCl-cotransporter in Gitelman's syndrome and primary hypertension."Hypertension 36:389-394(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Novel mutations in thiazide-sensitive Na-Cl cotransporter gene of patients with Gitelman's syndrome."J. Am. Soc. Nephrol. 11:65-70(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Gitelman's syndrome revisited: an evaluation of symptoms and health-related quality of life."Kidney Int. 59:710-717(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Severe hypomagnesaemia-induced hypocalcaemia in a patient with Gitelman's syndrome."Clin. Endocrinol. (Oxf.) 56:413-418(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Two novel mutations of thiazide-sensitive Na-Cl cotrans porter (TSC) gene in two sporadic Japanese patients with Gitelman syndrome."Endocr. J. 49:91-96(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of fifteen novel mutations in the SLC12A3 gene encoding the Na-Cl Co-transporter in Italian patients with Gitelman syndrome."Hum. Mutat. 20:78-78(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Four novel mutations in the thiazide-sensitive Na-Cl co-transporter gene in Japanese patients with Gitelman's syndrome."Nephrol. Dial. Transplant. 19:1761-1766(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Phenotype and genotype analysis in Chinese patients with Gitelman's syndrome."J. Clin. Endocrinol. Metab. 90:2500-2507(2005) [PubMed] [Europe PMC] [Abstract]
  18. "A novel mutation of the thiazide-sensitive sodium chloride cotransporter gene in a Japanese family with Gitelman syndrome."Clin. Nephrol. 65:57-60(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Novel mutations in the SLC12A3 gene causing Gitelman's syndrome in Swedes."DNA Seq. 18:395-399(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Two novel genotypes of the thiazide-sensitive Na-Cl cotransporter (SLC12A3) gene in patients with Gitelman's syndrome."Endocrine 31:149-153(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families."J. Hypertens. 25:2074-2081(2007) [PubMed] [Europe PMC] [Abstract]