Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1)
[Edit]BCO1; BCDO; BCDO1; BCMO; Beta-carotene dioxygenase 1; Beta-carotene oxygenase 1; Beta,beta-carotene 15,15'-monooxygenase
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Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. Beta-carotene 15,15-prime-monooxygenase (EC 1.13.11.21) is a key enzyme in beta-carotene metabolism to vitamin A.
Beta Carotene 15,15-Monooxygenase 1 a protein that shares 36.7% sequence identity with the bovine retinal pigment epithelium-specific gene Rpe65. They found that recombinant Drosophila Bcdo catalyzes centric cleavage of beta-carotene, resulting in the formation of 2 molecules of retinal. RT-PCR detected Bcdo expression exclusively in Drosophila head. Bcmo1 as critical molecular player for the regulation of PPARγ activity in adipocytes.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPE246Hu01 | Recombinant Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAE246Hu21 | Monoclonal Antibody to Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1) | WB; IHC; ICC; IP. |
| PAE246Hu01 | Polyclonal Antibody to Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1) | WB,IHC | |
| Assay Kits | SEE246Hu | ELISA Kit for Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEE246Ra | ELISA Kit for Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Cloning and characterization of a human beta,beta-carotene-15,15-prime dioxygenase that is highly expressed in the retinal pigment epithelium."Genomics 72:193-202(2001) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Loss-of-function mutation in carotenoid 15,15'-monooxygenase identified in a patient with hypercarotenemia and hypovitaminosis A."J. Nutr. 137:2346-2350(2007) [PubMed] [Europe PMC] [Abstract]