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Baculoviral IAP Repeat Containing Protein 6 (BIRC6)

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BRUCE; Apollon; BIR repeat-containing ubiquitin-conjugating enzyme; Ubiquitin-conjugating BIR domain enzyme apollon

Baculoviral IAP Repeat Containing Protein 6 (BIRC6)
CCC E233
HGNC 13516
MGI 1276108
PubMed 23287853
RGD 1307247
UniProt Q9NR09
Wiki BIRC6
Baculoviral IAP repeat-containing protein 6 is a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE233Hu01 Recombinant Baculoviral IAP Repeat Containing Protein 6 (BIRC6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE233Hu21 Monoclonal Antibody to Baculoviral IAP Repeat Containing Protein 6 (BIRC6) WB; IHC; ICC; IP.
PAE233Hu01 Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 6 (BIRC6) WB; IHC; ICC; IP.
Assay Kits SEE233Hu ELISA Kit for Baculoviral IAP Repeat Containing Protein 6 (BIRC6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Baculoviral IAP Repeat Containing Protein 6 (BIRC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Baculoviral IAP Repeat Containing Protein 6 (BIRC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 6 (BIRC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Baculoviral IAP Repeat Containing Protein 6 (BIRC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Baculoviral IAP Repeat Containing Protein 6 (BIRC6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Baculoviral IAP Repeat Containing Protein 6 (BIRC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Baculoviral IAP Repeat Containing Protein 6 (BIRC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 6 (BIRC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Baculoviral IAP Repeat Containing Protein 6 (BIRC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Baculoviral IAP Repeat Containing Protein 6 (BIRC6) ELISA Kit Customized Service Offer
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  2. "A human IAP-family gene, apollon, expressed in human brain cancer cells."Biochem. Biophys. Res. Commun. 264:847-854(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis."EMBO J. 23:800-810(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase."Mol. Cell 14:801-811(2004) [PubMed] [Europe PMC] [Abstract]
  7. "An Apollon vista of death and destruction."Nat. Cell Biol. 6:804-806(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."Cell 132:832-845(2008) [PubMed] [Europe PMC] [Abstract]
  10. "IAPs: more than just inhibitors of apoptosis proteins."Cell Cycle 7:1036-1046(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Ubc domain of the ubiquitin-protein ligase baculoviral IAP repeat-containing protein 6."Submitted (APR-2008) to the PDB data bank