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CREB Regulated Transcription Coactivator 2 (CRTC2)

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TORC2; Transducer of CREB protein 2; Transducer of regulated cAMP response element-binding protein 2

CREB Regulated Transcription Coactivator 2 (CRTC2)
CCC E000
HGNC 27301
MGI 1921593
PubMed 22495310
RGD 1308903
UniProt Q53ET0
Wiki CRTC2
TORC2, a CREB coactivator. This module consisted of the calcium-regulated phosphatase calcineurin and the ser/thr kinase SIK2, both of which associated with TORC2. Under resting conditions, TORC2 was sequestered in the cytoplasm via a phosphorylation-dependent interaction with 14-3-3 proteins. Triggering of the calcium and cAMP second messenger pathways by glucose and gut hormones disrupted TORC2:14-3-3 complexes via complementary effects on TORC2 dephosphorylation; calcium influx increased calcineurin activity, whereas cAMP inhibited SIK2 kinase activity. The results illustrated how a phosphatase/kinase module connects 2 signaling pathways in response to nutrient and hormonal cues. TORC2 shares 32% amino acid identity with TORC1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE000Hu01 Recombinant CREB Regulated Transcription Coactivator 2 (CRTC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to CREB Regulated Transcription Coactivator 2 (CRTC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CREB Regulated Transcription Coactivator 2 (CRTC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CREB Regulated Transcription Coactivator 2 (CRTC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CREB Regulated Transcription Coactivator 2 (CRTC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE000Mu01 Recombinant CREB Regulated Transcription Coactivator 2 (CRTC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to CREB Regulated Transcription Coactivator 2 (CRTC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CREB Regulated Transcription Coactivator 2 (CRTC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CREB Regulated Transcription Coactivator 2 (CRTC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CREB Regulated Transcription Coactivator 2 (CRTC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CREB Regulated Transcription Coactivator 2 (CRTC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CREB Regulated Transcription Coactivator 2 (CRTC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CREB Regulated Transcription Coactivator 2 (CRTC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CREB Regulated Transcription Coactivator 2 (CRTC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CREB Regulated Transcription Coactivator 2 (CRTC2) ELISA Kit Customized Service Offer
  1. "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells." Proc. Natl. Acad. Sci. U.S.A. 100:12147-12152(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "TORCs: transducers of regulated CREB activity."Mol. Cell 12:413-423(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector."Cell 119:61-74(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins."Curr. Biol. 14:2156-2161(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade."FEBS J. 273:2730-2748(2006) [PubMed] [Europe PMC] [Abstract]
  8. "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats."J. Virol. 80:7052-7059(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells."Proc. Natl. Acad. Sci. U.S.A. 103:14379-14384(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Dephosphorylation of TORC initiates expression of the StAR gene."Mol. Cell. Endocrinol. 265:196-204(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2."Proc. Natl. Acad. Sci. U.S.A. 105:10161-10166(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Single nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK alpha2-subunit (PRKAA2) and risk of type 2 diabetes."Mol. Genet. Metab. 93:200-209(2008) [PubMed] [Europe PMC] [Abstract]