≡

Pregnane X Receptor (PXR)

[Edit]

NR1I2; SAR; PAR1; PAR2; PRR; BXR; ONR1; PAR; PARq; SXR; Nuclear Receptor Subfamily 1,Group I,Member 2; Steroid and xenobiotic receptor; Pregnane X receptor

Pregnane X Receptor (PXR)
CCC D950
HGNC 7968
MGI 1337040
PubMed 12372848
RGD 69057
UniProt O75469
Wiki PXR
PXRbelongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain.
The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD950Hu01 Recombinant Pregnane X Receptor (PXR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD950Hu01 Polyclonal Antibody to Pregnane X Receptor (PXR) WB; IHC; ICC; IP.
MAD950Hu21 Monoclonal Antibody to Pregnane X Receptor (PXR) WB; IHC; ICC; IP.
Assay Kits SED950Hu ELISA Kit for Pregnane X Receptor (PXR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD950Mu01 Recombinant Pregnane X Receptor (PXR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD950Mu01 Polyclonal Antibody to Pregnane X Receptor (PXR) WB; IHC; ICC; IP.
LAD950Mu81 FITC-Linked Polyclonal Antibody to Pregnane X Receptor (PXR) WB; IHC; ICC; IF.
LAD950Mu71 Biotin-Linked Polyclonal Antibody to Pregnane X Receptor (PXR) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Pregnane X Receptor (PXR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pregnane X Receptor (PXR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD950Ra01 Recombinant Pregnane X Receptor (PXR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD950Ra01 Polyclonal Antibody to Pregnane X Receptor (PXR) WB; IHC; ICC; IP.
LAD950Ra81 FITC-Linked Polyclonal Antibody to Pregnane X Receptor (PXR) WB; IHC; ICC; IF.
LAD950Ra71 Biotin-Linked Polyclonal Antibody to Pregnane X Receptor (PXR) WB; IHC; ICC.
MAD950Ra21 Monoclonal Antibody to Pregnane X Receptor (PXR) WB; IHC; ICC; IP.
Assay Kits SED950Ra ELISA Kit for Pregnane X Receptor (PXR) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "SXR, a novel steroid and xenobiotic-sensing nuclear receptor."Genes Dev. 12:3195-3205(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions."J. Clin. Invest. 102:1016-1023(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction."Proc. Natl. Acad. Sci. U.S.A. 95:12208-12213(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants."Pharmacogenetics 11:555-572(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin."J. Biol. Chem. 276:14581-14587(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR."Mol. Pharmacol. 63:524-531(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner."J. Nutr. 139:898-904(2009) [PubMed] [Europe PMC] [Abstract]
  9. "The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity."Science 292:2329-2333(2001) [PubMed] [Europe PMC] [Abstract]
  10. "2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin."Biochemistry 42:1430-1438(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor."J. Mol. Biol. 331:815-828(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin."Mol. Endocrinol. 19:1125-1134(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism."Bioorg. Med. Chem. 15:2156-2166(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis of human pregnane X receptor activation by the hops constituent colupulone."Mol. Pharmacol. 74:1512-1520(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations." Drug Metab. Pharmacokinet. 17:561-565(2002) [PubMed] [Europe PMC] [Abstract]