5'-Nucleotidase, Cytosolic II (NT5C2)

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NT5B; PNT5; GMP; cN-II; NT5CP; Purine 5' Nucleotidase; 5'-Nucleotidase(Purine),Cytosolic Type B; Cytosolic purine 5'-nucleotidase

5'-Nucleotidase, Cytosolic II (NT5C2)
5' nucleotidases cleave off the phosphate from the 5' end of the sugar moiety. They can be classified into various kinds depending on their substrate preferences and subcellular localization. Membrane bound 5' nucleotidases displays specificity towards adenosine monophosphates and are predominantly involved in the salvage of preformed nucleotides and in signal transduction cascades involving purinergic receptors.Purine 5-prime-nucleotidase (EC 3.1.3.5) preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides, and is allosterically activated by various compounds, including ATP. NT5C2 is exclusively located in the cytoplasmic matrix of cells and may have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD941Hu01 Recombinant 5'-Nucleotidase, Cytosolic II (NT5C2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD941Hu01 Polyclonal Antibody to 5'-Nucleotidase, Cytosolic II (NT5C2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for 5'-Nucleotidase, Cytosolic II (NT5C2) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5'-Nucleotidase, Cytosolic II (NT5C2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5'-Nucleotidase, Cytosolic II (NT5C2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5'-Nucleotidase, Cytosolic II (NT5C2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5'-Nucleotidase, Cytosolic II (NT5C2) Polyclonal Antibody Customized Service Offer
Assay Kits SED941Mu ELISA Kit for 5'-Nucleotidase, Cytosolic II (NT5C2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning of human cytosolic purine 5'-nucleotidase."Biochem. Biophys. Res. Commun. 205:917-922(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders." Science 343:506-511(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition."J. Biol. Chem. 282:17828-17836(2007) [PubMed] [Europe PMC] [Abstract]