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Relaxin 2 (RLN2)

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H2; RLXH2; Relaxin H2; Prorelaxin H2; Relaxin,Ovarian,Of Pregnancy; Prorelaxin H2

Relaxin 2 (RLN2)
CCC D868
HGNC 10027
MGI 97931
PubMed 23141816
UniProt P04090
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3.RLN2 consists of an A chain and a B chain but their cleavage sites are not definitely described yet. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. Serelaxin, recombinant human relaxin-2, is a vasoactive peptide hormone with many biological and haemodynamic effects.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD868Hu01 Recombinant Relaxin 2 (RLN2) Positive Control; Immunogen; SDS-PAGE; WB.
CPD868Hu11 BSA Conjugated Relaxin 2 (RLN2) Immunogen; SDS-PAGE; WB.
CPD868Hu21 OVA Conjugated Relaxin 2 (RLN2) Immunogen; SDS-PAGE; WB.
Antibodies PAD868Hu01 Polyclonal Antibody to Relaxin 2 (RLN2) WB; IHC; ICC; IP.
Assay Kits SED868Hu ELISA Kit for Relaxin 2 (RLN2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Relaxin 2 (RLN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Relaxin 2 (RLN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Relaxin 2 (RLN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Relaxin 2 (RLN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Relaxin 2 (RLN2) ELISA Kit Customized Service Offer
  1. "Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones."EMBO J. 3:2333-2339(1984) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of human relaxin genes: characterization of a novel alternatively-spliced human relaxin mRNA species."Mol. Cell. Endocrinol. 118:85-94(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of the 5'-upstream regions of the human relaxin H1 and H2 genes and their chromosomal localization on chromosome 9p24.1 by radiation hybrid and breakpoint mapping."J. Mol. Endocrinol. 23:355-365(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Human seminal relaxin is a product of the same gene as human luteal relaxin."Endocrinology 130:2660-2668(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Structural characterization by mass spectrometry of native and recombinant human relaxin."Biomed. Environ. Mass Spectrom. 19:655-664(1990) [PubMed] [Europe PMC] [Abstract]
  8. "Total synthesis of human relaxin and human relaxin derivatives by solid-phase peptide synthesis and site-directed chain combination."J. Biol. Chem. 266:10754-10761(1991) [PubMed] [Europe PMC] [Abstract]
  9. "X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants."J. Mol. Biol. 221:15-21(1991) [PubMed] [Europe PMC] [Abstract]