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3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR)

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HMG-CoA Reductase; Hydroxymethylglutaryl-CoA Reductase

3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR)
CCC D686
HGNC 5006
MGI 96159
PubMed 21355415
RGD 2803
UniProt P04035
Wiki HMGCR
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase.
Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor as well as oxidized species of cholesterol. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Recombinant Protein Customized Service Offer
Antibodies PAD686Hu01 Polyclonal Antibody to 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) WB; IHC; ICC; IP.
Assay Kits SED686Hu ELISA Kit for 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD686Ra01 Recombinant 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD686Ra01 Polyclonal Antibody to 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) WB; IHC; ICC; IP.
MAD686Ra21 Monoclonal Antibody to 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) WB; IHC; ICC; IP.
Assay Kits SED686Ra ELISA Kit for 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Enzyme-linked immunosorbent assay for Antigen Detection.
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  8. "Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein."J. Biol. Chem. 286:32150-32161(2011) [PubMed] [Europe PMC] [Abstract]
  9. "A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus."BMC Mol. Biol. 13:29-29(2012) [PubMed] [Europe PMC] [Abstract]
  10. "The UBIAD1 prenyltransferase links menaquione-4 synthesis to cholesterol metabolic enzymes."Hum. Mutat. 34:317-329(2013) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis."EMBO J. 19:819-830(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Structural mechanism for statin inhibition of HMG-CoA reductase."Science 292:1160-1164(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase."J. Med. Chem. 51:3804-3813(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  16. ErratumNat. Genet. 23:373-373(1999)