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Acyl Coenzyme A Synthetase Long Chain Family, Member 4 (ACSL4)

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ACS4; FACL4; LACS4; MRX63; MRX68; Fatty-Acid-Coenzyme A Ligase,Long-Chain 4; Mental Retardation,X-Linked 63; Lignoceroyl-CoA Synthase

Acyl Coenzyme A Synthetase Long Chain Family, Member 4 (ACSL4)
CCC D674
HGNC 3571
MGI 1354713
PubMed 21903867
RGD 69401
UniProt O60488
Wiki ACSL4
Long-chain-fatty-acid--CoA ligase 4 is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation.
This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD674Hu01 Recombinant Acyl Coenzyme A Synthetase Long Chain Family, Member 4 (ACSL4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD674Hu01 Polyclonal Antibody to Acyl Coenzyme A Synthetase Long Chain Family, Member 4 (ACSL4) WB; IHC; ICC; IP.
Assay Kits SED674Hu ELISA Kit for Acyl Coenzyme A Synthetase Long Chain Family, Member 4 (ACSL4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acyl Coenzyme A Synthetase Long Chain Family, Member 4 (ACSL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acyl Coenzyme A Synthetase Long Chain Family, Member 4 (ACSL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acyl Coenzyme A Synthetase Long Chain Family, Member 4 (ACSL4) Polyclonal Antibody Customized Service Offer
Assay Kits SED674Mu ELISA Kit for Acyl Coenzyme A Synthetase Long Chain Family, Member 4 (ACSL4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD674Ra01 Recombinant Acyl Coenzyme A Synthetase Long Chain Family, Member 4 (ACSL4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD674Ra01 Polyclonal Antibody to Acyl Coenzyme A Synthetase Long Chain Family, Member 4 (ACSL4) WB; IHC; ICC; IP.
Assay Kits SED674Ra ELISA Kit for Acyl Coenzyme A Synthetase Long Chain Family, Member 4 (ACSL4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4)."Genomics 49:327-330(1998) [PubMed] [Europe PMC] [Abstract]
  2. "FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation."Genomics 47:350-358(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation."Nat. Genet. 30:436-440(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]