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ATP Binding Cassette Transporter B7 (ABCB7)

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ABC-B7; ABC7; ASAT; Atm1p; ATP-binding cassette sub-family B member 7, mitochondrial

ATP Binding Cassette Transporter B7 (ABCB7)
CCC D637
HGNC 48
MGI 109533
PubMed 23070040
UniProt O75027
Wiki ABCB7
ATP-binding cassette sub-family B member 7, mitochondrial is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD637Hu01 Recombinant ATP Binding Cassette Transporter B7 (ABCB7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD637Hu01 Polyclonal Antibody to ATP Binding Cassette Transporter B7 (ABCB7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter B7 (ABCB7) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter B7 (ABCB7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD637Mu01 Recombinant ATP Binding Cassette Transporter B7 (ABCB7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD637Mu01 Polyclonal Antibody to ATP Binding Cassette Transporter B7 (ABCB7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter B7 (ABCB7) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter B7 (ABCB7) ELISA Kit Customized Service Offer
  1. "Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia."J. Hum. Genet. 43:115-122(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)."Hum. Mol. Genet. 8:743-749(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation."Blood 96:3256-3264(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p."FEBS Lett. 441:266-270(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "X-linked cerebellar ataxia and sideroblastic anaemia associated with a missense mutation in the ABC7 gene predicting V411L."Br. J. Haematol. 115:910-917(2001) [PubMed] [Europe PMC] [Abstract]
  11. "X-linked sideroblastic anemia and ataxia: A new family with identification of a fourth ABCB7 gene mutation."Eur. J. Paediatr. Neurol. 16:730-735(2012) [PubMed] [Europe PMC] [Abstract]