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ATP Binding Cassette Transporter C4 (ABCC4)

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ABC-C4; MRP4; MOATB; Canalicular Multispecific Organic Anion Transporter B; Multidrug Resistance-Associated Protein 4; Multi-specific organic anion transporter B

ATP Binding Cassette Transporter C4 (ABCC4)
CCC D624
HGNC 55
MGI 2443111
PubMed 14643890
RGD 620266
UniProt O15439
Wiki ABCC4
ABCC4, also known as MRP4, belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus.
The insertion was attributed to 2 additional exons, designated 1a and 1b, that produced premature termination codons (PTCs). A comparison of human, monkey, and rodent ABCC4 genes revealed that these same PTC-producing exons were also highly conserved in evolution. In vitro inhibition of protein synthesis (using puromycin or anisomycin) selectively reduced nonsense-mediated mRNA decay of PTC-containing ABCC4 transcripts in all cell lines tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD624Hu01 Recombinant ATP Binding Cassette Transporter C4 (ABCC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD624Hu01 Polyclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) WB; IHC; ICC; IP.
MAD624Hu21 Monoclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) WB; IHC; ICC; IP.
Assay Kits SED624Hu ELISA Kit for ATP Binding Cassette Transporter C4 (ABCC4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter C4 (ABCC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter C4 (ABCC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter C4 (ABCC4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter C4 (ABCC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter C4 (ABCC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter C4 (ABCC4) ELISA Kit Customized Service Offer
  1. "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter."Cancer Res. 58:2741-2747(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing."J. Biol. Chem. 277:38998-39004(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines."Cancer Res. 57:3537-3547(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4."J. Biol. Chem. 287:15054-15065(2012) [PubMed] [Europe PMC] [Abstract]
  13. "6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4."Hum. Mutat. 29:659-669(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A Japanese-specific allele in the GALNT11 gene."Leg. Med. 12:208-211(2010) [PubMed] [Europe PMC] [Abstract]