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Mitogen Activated Protein Kinase 9 (MAPK9)

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JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; PRKM9; p54a; SAPK; Jun Kinase; Stress-activated protein kinase 1a; c-Jun N-terminal kinase 2

Mitogen Activated Protein Kinase 9 (MAPK9)
CCC D576
HGNC 6886
MGI 1346862
PubMed 21110917
RGD 628847
UniProt P45984
Wiki MAPK9
Mitogen-activated protein kinase 9 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD576Hu01 Recombinant Mitogen Activated Protein Kinase 9 (MAPK9) Positive Control; Immunogen; SDS-PAGE; WB.
RPD576Hu02 Recombinant Mitogen Activated Protein Kinase 9 (MAPK9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD576Hu01 Polyclonal Antibody to Mitogen Activated Protein Kinase 9 (MAPK9) WB; IHC; ICC; IP.
Assay Kits SED576Hu ELISA Kit for Mitogen Activated Protein Kinase 9 (MAPK9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase 9 (MAPK9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase 9 (MAPK9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase 9 (MAPK9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 9 (MAPK9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 9 (MAPK9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase 9 (MAPK9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase 9 (MAPK9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase 9 (MAPK9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 9 (MAPK9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 9 (MAPK9) ELISA Kit Customized Service Offer
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  7. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  10. "Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7."Biochem. J. 352:145-154(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein."Biochem. J. 389:73-82(2005) [PubMed] [Europe PMC] [Abstract]
  12. "The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis."Genes Dev. 19:933-941(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation."Cancer Res. 67:8725-8735(2007) [PubMed] [Europe PMC] [Abstract]
  14. "The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway."Immunity 26:55-66(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway."Oncogene 26:7222-7230(2007) [PubMed] [Europe PMC] [Abstract]
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  17. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  18. "GSK3beta is involved in JNK2-mediated beta-catenin inhibition."PLoS ONE 4:E6640-E6640(2009) [PubMed] [Europe PMC] [Abstract]
  19. "c-Jun NH2-terminal kinase-2 mediates osmotic stress-induced tight junction disruption in the intestinal epithelium."Am. J. Physiol. 299:G572-G584(2010) [PubMed] [Europe PMC] [Abstract]
  20. "JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis."Cell Death Dis. 1:E29-E29(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "JNK regulates the photic response of the mammalian circadian clock."EMBO Rep. 13:455-461(2012) [PubMed] [Europe PMC] [Abstract]
  23. "The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity."J. Mol. Biol. 383:885-893(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]