Antithrombin Thrombin Heparin Ternary Complex (TAT-H)

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Antithrombin Thrombin Heparin Ternary Complex (TAT-H)
The maintenance of normal blood flow depends completely on the inhibition of thrombin by antithrombin, a member of the serpin family. Antithrombin circulates at a high concentration, but only becomes capable of efficient thrombin inhibition on interaction with heparin or related glycosaminoglycans. The anticoagulant properties of therapeutic heparin are mediated by its interaction with antithrombin, although the structural basis for this interaction is unclear. The crystal structure at a resolution of 2.5 A of the ternary complex between antithrombin, thrombin and a heparin mimetic . The structure reveals a template mechanism with antithrombin and thrombin bound to the same heparin chain. A notably close contact interface, comprised of extensive active site and exosite interactions, explains, in molecular detail, the basis of the antithrombotic properties of therapeutic heparin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Antithrombin Thrombin Heparin Ternary Complex (TAT-H) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Antithrombin Thrombin Heparin Ternary Complex (TAT-H) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Antithrombin Thrombin Heparin Ternary Complex (TAT-H) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Antithrombin Thrombin Heparin Ternary Complex (TAT-H) CLIA Kit Customized Service Offer
n/a ELISA Kit for Antithrombin Thrombin Heparin Ternary Complex (TAT-H) ELISA Kit Customized Service Offer