Heat Shock 70kDa Binding Protein 1 (HSPBP1)

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FES1; Hsp70 Interacting Protein; Hsp70 Binding Protein,Cytoplasmic Cochaperone 1; Heat shock protein-binding protein 1; Hsp70-interacting protein 1

Heat Shock 70kDa Binding Protein 1 (HSPBP1)
Using the ATPase domain of human HSP70 as bait in a yeast 2-hybrid screen of a human heart cDNA library, Raynes and Guerriero (1998) cloned HSPBP1. The deduced 459-amino acid protein has a calculated molecular mass of 39.3 kD and contains 6 consecutive glycines near its N terminus. Northern blot analysis detected a 1.7-kb HSPBP1 transcript in all tissues examined, with highest expression in heart and skeletal muscle.
Raynes and Guerriero (1998) also identified an HSPBP1 variant that they called HSPBP2, which has 2 polyadenylation signals rather than the single polyadenylation signal of HSPBP1. The deduced HSPBP2 protein is identical to HSPBP1 except that it has 9 consecutive glycines near the N terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD506Hu01 Recombinant Heat Shock 70kDa Binding Protein 1 (HSPBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD506Hu01 Polyclonal Antibody to Heat Shock 70kDa Binding Protein 1 (HSPBP1) WB; IHC; ICC; IP.
LAD506Hu71 Biotin-Linked Polyclonal Antibody to Heat Shock 70kDa Binding Protein 1 (HSPBP1) WB; IHC; ICC.
MAD506Hu21 Monoclonal Antibody to Heat Shock 70kDa Binding Protein 1 (HSPBP1) WB; IHC; ICC; IP.
Assay Kits SED506Hu ELISA Kit for Heat Shock 70kDa Binding Protein 1 (HSPBP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD506Mu01 Recombinant Heat Shock 70kDa Binding Protein 1 (HSPBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD506Mu01 Polyclonal Antibody to Heat Shock 70kDa Binding Protein 1 (HSPBP1) WB,IHC
LAD506Mu71 Biotin-Linked Polyclonal Antibody to Heat Shock 70kDa Binding Protein 1 (HSPBP1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Heat Shock 70kDa Binding Protein 1 (HSPBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heat Shock 70kDa Binding Protein 1 (HSPBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD506Ra01 Recombinant Heat Shock 70kDa Binding Protein 1 (HSPBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD506Ra01 Polyclonal Antibody to Heat Shock 70kDa Binding Protein 1 (HSPBP1) WB; IHC; ICC; IP.
LAD506Ra71 Biotin-Linked Polyclonal Antibody to Heat Shock 70kDa Binding Protein 1 (HSPBP1) WB; IHC; ICC.
CAD506Mi01 Anti-Heat Shock 70kDa Binding Protein 1 (HSPBP1) Polyclonal Antibody Loading Control of WB.
MAD506Ra23 Monoclonal Antibody to Heat Shock 70kDa Binding Protein 1 (HSPBP1) WB; IHC; ICC; IP.
MAD506Ra21 Monoclonal Antibody to Heat Shock 70kDa Binding Protein 1 (HSPBP1) WB; IHC; ICC; IP.
MAD506Ra22 Monoclonal Antibody to Heat Shock 70kDa Binding Protein 1 (HSPBP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Heat Shock 70kDa Binding Protein 1 (HSPBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heat Shock 70kDa Binding Protein 1 (HSPBP1) ELISA Kit Customized Service Offer
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  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange."Mol. Cell 17:367-379(2005) [PubMed] [Europe PMC] [Abstract]