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Hypoxia Inducible Factor 3 Alpha (HIF3a)

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HIF-3A; HIF-3A4; IPAS; MOP7; PASD7; Basic-helix-loop-helix-PAS protein MOP7; Class E basic helix-loop-helix protein 17; Inhibitory PAS domain protein

Hypoxia Inducible Factor 3 Alpha (HIF3a)
CCC D467
HGNC 15825
MGI 1859778
PubMed 19755485
RGD 70332
UniProt Q9Y2N7
Wiki HIF3A
Hypoxia-inducible factor 3 alpha is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits.
It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. At least three transcript variants encoding three different isoforms have been found for this gene.Expressed in kidney. Expressed abundantly in lung epithelial cells. Expression is regulated in an oxygen- dependent manner.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hypoxia Inducible Factor 3 Alpha (HIF3a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hypoxia Inducible Factor 3 Alpha (HIF3a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hypoxia Inducible Factor 3 Alpha (HIF3a) Polyclonal Antibody Customized Service Offer
Assay Kits SED467Hu ELISA Kit for Hypoxia Inducible Factor 3 Alpha (HIF3a) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hypoxia Inducible Factor 3 Alpha (HIF3a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hypoxia Inducible Factor 3 Alpha (HIF3a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hypoxia Inducible Factor 3 Alpha (HIF3a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hypoxia Inducible Factor 3 Alpha (HIF3a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hypoxia Inducible Factor 3 Alpha (HIF3a) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hypoxia Inducible Factor 3 Alpha (HIF3a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hypoxia Inducible Factor 3 Alpha (HIF3a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hypoxia Inducible Factor 3 Alpha (HIF3a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hypoxia Inducible Factor 3 Alpha (HIF3a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hypoxia Inducible Factor 3 Alpha (HIF3a) ELISA Kit Customized Service Offer
  1. "Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha."Biochem. Biophys. Res. Commun. 287:808-813(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma."FASEB J. 19:1396-1406(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex."J. Biol. Chem. 278:11032-11040(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha."Cell Res. 16:548-558(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Dominant-negative HIF-3 alpha 4 suppresses VHL-null renal cell carcinoma progression."Cell Cycle 6:2810-2816(2007) [PubMed] [Europe PMC] [Abstract]
  9. "The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction."Biochem. J. 424:143-151(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2."Int. J. Biochem. Cell Biol. 42:1189-1200(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Cell-specific and hypoxia-dependent regulation of human HIF-3alpha: inhibition of the expression of HIF target genes in vascular cells."Cell. Mol. Life Sci. 68:2627-2642(2011) [PubMed] [Europe PMC] [Abstract]