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Sjogren Syndrome Antigen B (SSB)

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LARP3; Lupus La Protein; Autoantigen La; La Ribonucleoprotein Domain Family,Member 3; Autoantigen SSB/La

Sjogren Syndrome Antigen B (SSB)
CCC D199
HGNC 11316
MGI 98423
PubMed 23129761
RGD 620804
UniProt P05455
Wiki SSB
Sjogren syndrome antigen B (autoantigen La), also known as SSB,La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus (SLE) (Teplova et al., 2006).Grolz and Bachmann (1997) stated that there are 3 La pseudogenes. They also found that alternative splicing gives rise to 3 different mRNAs, all of which were expressed in all tissues tested, and all of which were translated into nuclear La protein in transfected mouse cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD199Hu01 Recombinant Sjogren Syndrome Antigen B (SSB) Positive Control; Immunogen; SDS-PAGE; WB.
EPD199Hu61 Eukaryotic Sjogren Syndrome Antigen B (SSB) Positive Control; Immunogen; SDS-PAGE; WB.
EPD199Hu62 Eukaryotic Sjogren Syndrome Antigen B (SSB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD199Hu01 Polyclonal Antibody to Sjogren Syndrome Antigen B (SSB) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Sjogren Syndrome Antigen B (SSB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sjogren Syndrome Antigen B (SSB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD199Mu01 Recombinant Sjogren Syndrome Antigen B (SSB) Positive Control; Immunogen; SDS-PAGE; WB.
RPD199Mu02 Recombinant Sjogren Syndrome Antigen B (SSB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD199Mu01 Polyclonal Antibody to Sjogren Syndrome Antigen B (SSB) WB; IHC; ICC; IP.
PAD199Mu02 Polyclonal Antibody to Sjogren Syndrome Antigen B (SSB) WB; IHC; ICC; IP.
Assay Kits SED199Mu ELISA Kit for Sjogren Syndrome Antigen B (SSB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sjogren Syndrome Antigen B (SSB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sjogren Syndrome Antigen B (SSB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sjogren Syndrome Antigen B (SSB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sjogren Syndrome Antigen B (SSB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sjogren Syndrome Antigen B (SSB) ELISA Kit Customized Service Offer
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  11. "Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes."Mol. Biol. Cell 15:611-624(2004) [PubMed] [Europe PMC] [Abstract]
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  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element."Structure 11:833-843(2003) [PubMed] [Europe PMC] [Abstract]
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  26. "Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein."Structure 16:852-862(2008) [PubMed] [Europe PMC] [Abstract]