Hemoglobin Alpha 2 (HBa2)

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Alpha-globin

Hemoglobin Alpha 2 (HBa2)
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- ζ - pseudo ζ - μ - pseudo α121 - θ3'. The α2 (HBA2) and α1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two α-chains plus two-β chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hemoglobin Alpha 2 (HBa2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hemoglobin Alpha 2 (HBa2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hemoglobin Alpha 2 (HBa2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hemoglobin Alpha 2 (HBa2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hemoglobin Alpha 2 (HBa2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hemoglobin Alpha 2 (HBa2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hemoglobin Alpha 2 (HBa2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hemoglobin Alpha 2 (HBa2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hemoglobin Alpha 2 (HBa2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hemoglobin Alpha 2 (HBa2) ELISA Kit Customized Service Offer
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  24. "Accommodation of insertions in helices: the mutation in hemoglobin Catonsville (Pro 37 alpha-Glu-Thr 38 alpha) generates a 3(10)-->alpha bulge."Biochemistry 32:2509-2513(1993) [PubMed] [Europe PMC] [Abstract]
  25. "HB Al-Ain Abu Dhabi [alpha 18(A16)Gly-->Asp]: a new hemoglobin variant discovered in an Emiratee family."Hemoglobin 16:355-362(1992) [PubMed] [Europe PMC] [Abstract]
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  27. "Hb Auckland [alpha 87(F8) His-->Asn]: a new mutation of the proximal histidine identified by electrospray mass spectrometry."Hemoglobin 21:393-403(1997) [PubMed] [Europe PMC] [Abstract]
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  30. "Hemoglobin Chongqing [alpha 2(NA2)Leu-->Arg] and hemoglobin Harbin [alpha 16(A14)Lys-->Met] found in China."Hemoglobin 8:569-581(1984) [PubMed] [Europe PMC] [Abstract]
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  36. "Hemoglobin Grady: the first example of a variant with elongated chains due to an insertion of residues."Proc. Natl. Acad. Sci. U.S.A. 71:3270-3273(1974) [PubMed] [Europe PMC] [Abstract]
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  46. "Hb Melusine [alpha 114(GH2)Pro-->Ser]: a new neutral hemoglobin variant."Hemoglobin 17:397-405(1993) [PubMed] [Europe PMC] [Abstract]
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  48. "Hemoglobin Petah Tikva (alpha 110 Ala replaced by Asp): a new unstable variant with alpha-thalassemia-like expression."Blood 57:705-711(1981) [PubMed] [Europe PMC] [Abstract]
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  50. "Hb Port Huron [alpha 56 (E5)Lys-->Arg]: a new alpha chain variant."Hemoglobin 15:381-391(1991) [PubMed] [Europe PMC] [Abstract]
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  53. "Hemoglobin Suan-Dok (alpha 2 109 (G16) Leu replaced by Arg beta 2): an unstable variant associated with alpha-thalassemia."Hemoglobin 3:161-174(1979) [PubMed] [Europe PMC] [Abstract]
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  56. "HB Swan River [alpha 6(A4)Asp-->Gly] observed in a Japanese man."Hemoglobin 20:75-78(1996) [PubMed] [Europe PMC] [Abstract]
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  59. "A new alpha chain variant, Hb Turriff [alpha 99(G6)Lys-->Glu]: the interference of abnormal hemoglobins in Hb A1c determination."Hemoglobin 16:11-17(1992) [PubMed] [Europe PMC] [Abstract]
  60. "Hb Val de Marne [alpha 133(H16)Ser-->Arg]: a new hemoglobin variant with moderate increase in oxygen affinity."Hemoglobin 17:407-417(1993) [PubMed] [Europe PMC] [Abstract]
  61. "Hb Westmead: an alpha 2-globin gene mutation detected by polymerase chain reaction and Stu I cleavage."Hemoglobin 15:291-295(1991) [PubMed] [Europe PMC] [Abstract]
  62. "Hemoglobin Woodville: alpha (2)6(A4) aspartic acid-->tyrosine."Hemoglobin 10:135-141(1986) [PubMed] [Europe PMC] [Abstract]
  63. "Hb Yuda or alpha 130(H13)Ala-->Asp; a new alpha chain variant with low oxygen affinity."Hemoglobin 16:435-439(1992) [PubMed] [Europe PMC] [Abstract]
  64. "Two new human hemoglobin variants caused by unusual mutational events: Hb Zaire contains a five residue repetition within the alpha-chain and Hb Duino has two residues substituted in the beta-chain."Hum. Genet. 89:676-680(1992) [PubMed] [Europe PMC] [Abstract]
  65. "Hb Aghia Sophia [alpha62(E11)Val-->0 (alpha1)], an 'in-frame' deletion causing alpha-thalassemia."Hemoglobin 23:317-324(1999) [PubMed] [Europe PMC] [Abstract]
  66. "Two new alpha chain variants: Hb Boghe [alpha58(E7)His-->Gln, alpha2], a variant on the distal histidine, and Hb Charolles [alpha103(G10)His-Tyr, alpha1]."Hemoglobin 23:345-352(1999) [PubMed] [Europe PMC] [Abstract]
  67. "Screening for mutations in human alpha-globin genes by nonradioactive single-strand conformation polymorphism."Braz. J. Med. Biol. Res. 36:1471-1474(2003) [PubMed] [Europe PMC] [Abstract]
  68. "Characterization of hemoglobin Bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity."Am. J. Hematol. 77:268-276(2004) [PubMed] [Europe PMC] [Abstract]
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