≡

Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR)

[Edit]

LGR2; HLHR; LCGR; LHR; Lutropin/Choriogonadotropin Receptor; Luteinizing Hormone Receptor; Lutropin-choriogonadotropic hormone receptor

Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR)
CCC D047
HGNC 6585
MGI 96783
PubMed 23232123
RGD 3007
UniProt P22888
Wiki LHCGR
LHCGR is a transmembrane receptor found in ovary, testis and extragonodal organs like uterus, that receptor interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning during reproduction. LHCGRs are found in the ovary, testis, and many extragonadal tissues.
The gene for the LHCGR is found on chromosome 2 p21 in humans, close to the FSH receptor gene. It consists of 70 kbp (versus 54 kpb for the FSHR). The gene is similar to the gene for the FSH receptor and the TSH receptor.The LHCGR consists of 674 amino acids and has a molecular mass of about 85-95 kDA based on the extent of glycolization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) ELISA Kit Customized Service Offer
  1. "Cloning and sequencing of human LH/hCG receptor cDNA."Biochem. Biophys. Res. Commun. 172:1049-1054(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of human luteinizing hormone (LH) receptor: interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species."Mol. Endocrinol. 5:759-768(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing."Mol. Endocrinol. 4:1264-1276(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Structure of the human luteinizing hormone-choriogonadotropin receptor gene: unusual promoter and 5' non-coding regions."Mol. Cell. Endocrinol. 111:113-123(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Genomic distribution and gonadal mRNA expression of two human luteinizing hormone receptor exon 1 sequences in random populations."Hum. Hered. 49:48-51(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Evidence that palmitoylation of carboxyl terminus cysteine residues of the human luteinizing hormone receptor regulates postendocytic processing."Mol. Endocrinol. 19:749-758(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions."Structure 3:1341-1353(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Gonadotropin-independent precocious puberty due to luteinizing hormone receptor mutations in Brazilian boys: a novel constitutively activating mutation in the first transmembrane helix."J. Clin. Endocrinol. Metab. 85:4799-4805(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Nodular Leydig cell hyperplasia in a boy with familial male-limited precocious puberty."J. Pediatr. 138:949-951(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Mutant luteinizing hormone receptors in a compound heterozygous patient with complete Leydig cell hypoplasia: abnormal processing causes signaling deficiency."J. Clin. Endocrinol. Metab. 87:2506-2513(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Luteinizing hormone signaling and breast cancer: polymorphisms and age of onset."J. Clin. Endocrinol. Metab. 88:1653-1657(2003) [PubMed] [Europe PMC] [Abstract]
  13. "A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty."Nature 365:652-654(1993) [PubMed] [Europe PMC] [Abstract]
  14. "Cosegregation of missense mutations of the luteinizing hormone receptor gene with familial male-limited precocious puberty."Hum. Mol. Genet. 2:1779-1783(1993) [PubMed] [Europe PMC] [Abstract]
  15. "Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty."Hum. Mol. Genet. 4:183-188(1995) [PubMed] [Europe PMC] [Abstract]
  16. "A new constitutively activating point mutation in the luteinizing hormone/choriogonadotropin receptor gene in cases of male-limited precocious puberty."J. Clin. Endocrinol. Metab. 80:1162-1168(1995) [PubMed] [Europe PMC] [Abstract]
  17. "A novel mutation of the luteinizing hormone receptor gene causing male gonadotropin-independent precocious puberty."J. Clin. Endocrinol. Metab. 80:2490-2494(1995) [PubMed] [Europe PMC] [Abstract]
  18. "Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene."Nat. Genet. 9:160-164(1995) [PubMed] [Europe PMC] [Abstract]
  19. "A missense (T577I) mutation in the luteinizing hormone receptor gene associated with familial male-limited precocious puberty."Hum. Mutat. 7:164-166(1996) [PubMed] [Europe PMC] [Abstract]
  20. "A new point mutation in the luteinising hormone receptor gene in familial and sporadic male limited precocious puberty: genotype does not always correlate with phenotype."J. Med. Genet. 33:143-147(1996) [PubMed] [Europe PMC] [Abstract]
  21. "Testicular and ovarian resistance to luteinizing hormone caused by inactivating mutations of the luteinizing hormone-receptor gene."N. Engl. J. Med. 334:507-512(1996) [PubMed] [Europe PMC] [Abstract]
  22. "Comparison of immunocytochemical and molecular features with the phenotype in a case of incomplete male pseudohermaphroditism associated with a mutation of the luteinizing hormone receptor."J. Clin. Endocrinol. Metab. 82:2159-2165(1997) [PubMed] [Europe PMC] [Abstract]
  23. "Polymorphisms in the coding exons of the human luteinizing hormone receptor gene."Hum. Mutat. 11:333-334(1998) [PubMed] [Europe PMC] [Abstract]
  24. "A mutation in the first transmembrane domain of the lutropin receptor causes male precocious puberty."J. Clin. Endocrinol. Metab. 83:476-480(1998) [PubMed] [Europe PMC] [Abstract]
  25. "A novel mutation of the human luteinizing hormone receptor in 46XY and 46XX sisters."J. Clin. Endocrinol. Metab. 83:2091-2098(1998) [PubMed] [Europe PMC] [Abstract]
  26. "A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty."J. Clin. Endocrinol. Metab. 83:2435-2440(1998) [PubMed] [Europe PMC] [Abstract]
  27. "Evidences for an allelic variant of the human LC/CG receptor rather than a gene duplication: functional comparison of wild-type and variant receptors."J. Clin. Endocrinol. Metab. 83:4431-4434(1998) [PubMed] [Europe PMC] [Abstract]
  28. "A homozygous microdeletion in helix 7 of the luteinizing hormone receptor associated with familial testicular and ovarian resistance is due to both decreased cell surface expression and impaired effector activation by the cell surface receptor."Mol. Endocrinol. 12:442-450(1998) [PubMed] [Europe PMC] [Abstract]
  29. "A homozygous mutation in the luteinizing hormone receptor causes partial Leydig cell hypoplasia: correlation between receptor activity and phenotype."Mol. Endocrinol. 12:775-784(1998) [PubMed] [Europe PMC] [Abstract]
  30. "Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor."N. Engl. J. Med. 341:1731-1736(1999) [PubMed] [Europe PMC] [Abstract]
  31. "A novel missense homozygous inactivating mutation in the fourth transmembrane helix of the luteinizing hormone receptor in Leydig cell hypoplasia."Am. J. Med. Genet. A 130:146-153(2004) [PubMed] [Europe PMC] [Abstract]
  32. "Leydig cell hypoplasia: absent luteinizing hormone receptor cell surface expression caused by a novel homozygous mutation in the extracellular domain."J. Clin. Endocrinol. Metab. 89:5161-5167(2004) [PubMed] [Europe PMC] [Abstract]
  33. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  34. "A splice site mutation combined with a novel missense mutation of LHCGR cause male pseudohermaphroditism."Hum. Mutat. 30:E855-E865(2009) [PubMed] [Europe PMC] [Abstract]