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Neuropilin 2 (NRP2)

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NP2; NPN2; VEGF165R2; VEGF165-R2; Vascular endothelial cell growth factor 165 receptor 2

Neuropilin 2 (NRP2)
CCC D042
HGNC 8005
MGI 1100492
PubMed 9331348
RGD 621442
UniProt O60462
Wiki NRP2
Neuropilin-2 is a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.Neuropilins work as co-receptors as they have a very small cytoplasmic domain and thus rely upon other molecules to transduce their signals across a cell membrane, normally Plexins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD042Hu01 Recombinant Neuropilin 2 (NRP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD042Hu01 Polyclonal Antibody to Neuropilin 2 (NRP2) WB; IHC; ICC; IP.
MAD042Hu21 Monoclonal Antibody to Neuropilin 2 (NRP2) WB; IHC; ICC; IP.
Assay Kits SED042Hu ELISA Kit for Neuropilin 2 (NRP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neuropilin 2 (NRP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neuropilin 2 (NRP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuropilin 2 (NRP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuropilin 2 (NRP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuropilin 2 (NRP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD042Ra01 Recombinant Neuropilin 2 (NRP2) Positive Control; Immunogen; SDS-PAGE; WB.
RPD042Ra02 Recombinant Neuropilin 2 (NRP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD042Ra01 Polyclonal Antibody to Neuropilin 2 (NRP2) WB; IHC; ICC; IP.
LAD042Ra81 FITC-Linked Polyclonal Antibody to Neuropilin 2 (NRP2) WB; IHC; ICC; IF.
LAD042Ra71 Biotin-Linked Polyclonal Antibody to Neuropilin 2 (NRP2) WB; IHC; ICC.
MAD042Ra22 Monoclonal Antibody to Neuropilin 2 (NRP2) WB; IHC; ICC; IP.
PAD042Ra02 Polyclonal Antibody to Neuropilin 2 (NRP2) WB; IHC; ICC; IP.
MAD042Ra21 Monoclonal Antibody to Neuropilin 2 (NRP2) WB; IHC; ICC; IP.
Assay Kits SED042Ra ELISA Kit for Neuropilin 2 (NRP2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III."Neuron 19:547-559(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor."Cell 92:735-745(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms."Genomics 70:211-222(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165."J. Biol. Chem. 275:18040-18045(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."Cell 99:71-80(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding."EMBO J. 26:4902-4912(2007) [PubMed] [Europe PMC] [Abstract]
  9. "de novo pathogenic SCN8A mutation identified by whole-genome sequencing of a family quartet affected by infantile epileptic encephalopathy and SUDEP."Am. J. Hum. Genet. 90:502-510(2012) [PubMed] [Europe PMC] [Abstract]