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Immunoglobulin J (IgJ)

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IGCJ; JCH; Immunoglobulin J Polypeptide,Linker Protein For Immunoglobulin Alpha And Mu Polypeptides

Immunoglobulin J (IgJ)
CCC D039
HGNC 5713
MGI 96493
PubMed 2415140
RGD 1310155
UniProt P01591
J chain is a 137-amino acid protein that is synthesized in B lymphocytes and serves 2 known functions: linking immunoglobulin monomers (IgM to pentamers, IgA to dimers) and binding these immunoglobulins to secretory component (Koshland, 1985). Using probes from J chain clones, Max et al. (1986) assigned the J chain gene to 4q21 by Southern analysis of somatic cell hybrids and by in situ hybridization. This band is the site of translocations with chromosome 11 in some acute lymphocytic leukemias. In the mouse, JCH maps to chromosome 5 which carries 4 other genes that are also on human no. 4 (PGM2, PEPS, ALB, and AFP). Max et al. (1986) also discovered genetic variation in the number of repeats of a 27-bp sequence that is tandemly reduplicated 5-prime of the human J chain gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Immunoglobulin J (IgJ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Immunoglobulin J (IgJ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Immunoglobulin J (IgJ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Immunoglobulin J (IgJ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin J (IgJ) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Immunoglobulin J (IgJ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Immunoglobulin J (IgJ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Immunoglobulin J (IgJ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Immunoglobulin J (IgJ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin J (IgJ) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Immunoglobulin J (IgJ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Immunoglobulin J (IgJ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Immunoglobulin J (IgJ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Immunoglobulin J (IgJ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin J (IgJ) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Primary structure of human J chain: alignment of peptides from chemical and enzymatic hydrolyses."Biochemistry 16:3507-3513(1977) [PubMed] [Europe PMC] [Abstract]
  3. "Human J chain gene. Structure and expression in B lymphoid cells."J. Exp. Med. 161:832-849(1985) [PubMed] [Europe PMC] [Abstract]
  4. "Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M."Biochemistry 31:12643-12647(1992) [PubMed] [Europe PMC] [Abstract]
  5. "A proteomic analysis of human bile."Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]