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Ferritin, Light Polypeptide (FTL)

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Ferritin Light Chain; Ferritin Light Polypeptide-Like 3; L Apoferritin; Ferritin L Subunit

Ferritin, Light Polypeptide (FTL)
CCC D020
HGNC 3999
MGI 95590
PubMed 11438811
RGD 61813
UniProt P02792
Wiki FTL
Ferritin light chain is an abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART.
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD020Hu01 Recombinant Ferritin, Light Polypeptide (FTL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD020Hu01 Polyclonal Antibody to Ferritin, Light Polypeptide (FTL) WB; IHC
LAD020Hu71 Biotin-Linked Polyclonal Antibody to Ferritin, Light Polypeptide (FTL) WB; IHC; ICC.
LAD020Hu81 FITC-Linked Polyclonal Antibody to Ferritin, Light Polypeptide (FTL) WB; IHC; ICC; IF.
MAD020Hu21 Monoclonal Antibody to Ferritin, Light Polypeptide (FTL) WB,IHC
MAD020Hu22 Monoclonal Antibody to Ferritin, Light Polypeptide (FTL) WB; IHC
MAD020Hu23 Monoclonal Antibody to Ferritin, Light Polypeptide (FTL) WB; IHC; ICC; IP.
MAD020Hu24 Monoclonal Antibody to Ferritin, Light Polypeptide (FTL) WB; IHC; ICC; IP.
MAD020Hu25 Monoclonal Antibody to Ferritin, Light Polypeptide (FTL) WB,IHC
Assay Kits SED020Hu ELISA Kit for Ferritin, Light Polypeptide (FTL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD020Mu01 Recombinant Ferritin, Light Polypeptide (FTL) Positive Control; Immunogen; SDS-PAGE; WB.
RPD020Mu02 Recombinant Ferritin, Light Polypeptide (FTL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD020Mu01 Polyclonal Antibody to Ferritin, Light Polypeptide (FTL) WB,IHC
PAD020Mu02 Polyclonal Antibody to Ferritin, Light Polypeptide (FTL) WB; IHC; ICC; IP.
Assay Kits SED020Mu ELISA Kit for Ferritin, Light Polypeptide (FTL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD020Ra01 Recombinant Ferritin, Light Polypeptide (FTL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD020Ra01 Polyclonal Antibody to Ferritin, Light Polypeptide (FTL) WB; IHC; ICC; IP.
MAD020Ra21 Monoclonal Antibody to Ferritin, Light Polypeptide (FTL) WB; IHC; ICC; IP.
Assay Kits SED020Ra ELISA Kit for Ferritin, Light Polypeptide (FTL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD020Bo01 Recombinant Ferritin, Light Polypeptide (FTL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD020Bo01 Polyclonal Antibody to Ferritin, Light Polypeptide (FTL) WB; IHC; ICC; IP.
Assay Kits SED020Bo ELISA Kit for Ferritin, Light Polypeptide (FTL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD020Eq01 Recombinant Ferritin, Light Polypeptide (FTL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD020Eq01 Polyclonal Antibody to Ferritin, Light Polypeptide (FTL) WB; IHC; ICC; IP.
LAD020Eq71 Biotin-Linked Polyclonal Antibody to Ferritin, Light Polypeptide (FTL) WB; IHC; ICC.
LAD020Eq81 FITC-Linked Polyclonal Antibody to Ferritin, Light Polypeptide (FTL) WB; IHC; ICC; IF.
Assay Kits SED020Eq ELISA Kit for Ferritin, Light Polypeptide (FTL) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones."J. Biol. Chem. 260:11755-11761(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of human ferritin light subunit messenger RNA: comparison with heavy subunit message and functional implications."Proc. Natl. Acad. Sci. U.S.A. 82:3139-3143(1985) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of the gene coding for human L apoferritin."Nucleic Acids Res. 14:2863-2876(1986) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro."Mol. Cell. Biol. 6:566-573(1986) [PubMed] [Europe PMC] [Abstract]
  9. "The amino acid sequence of human liver apoferritin."FEBS Lett. 164:139-144(1983) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome."J. Exp. Med. 210:1779-1791(2013) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Structure of human ferritin L chain."Acta Crystallogr. D 62:800-806(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration."J. Biol. Chem. 285:1950-1956(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation."J. Biol. Chem. 285:11948-11957(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Neuroferritinopathy: missense mutation in FTL causing early-onset bilateral pallidal involvement."Neurology 65:603-605(2005) [PubMed] [Europe PMC] [Abstract]
  18. "A new missense mutation in the L ferritin coding sequence associated with elevated levels of glycosylated ferritin in serum and absence of iron overload."Haematologica 94:335-339(2009) [PubMed] [Europe PMC] [Abstract]