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Glutamate Decarboxylase 1, Brain (GAD1)

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GAD67; SCP; 67 kDa glutamic acid decarboxylase; Glutamate decarboxylase 67 kDa isoform

Glutamate Decarboxylase 1, Brain (GAD1)
CCC C904
HGNC 4092
MGI 95632
PubMed 15604684
RGD 2652
UniProt Q99259
Wiki GAD1
Glutamate decarboxylase 1 (brain, 67kDa) is one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes.
This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutamate Decarboxylase 1, Brain (GAD1) Recombinant Protein Customized Service Offer
Antibodies MAC904Hu22 Monoclonal Antibody to Glutamate Decarboxylase 1, Brain (GAD1) WB; IHC; ICC; IP.
Assay Kits SEC904Hu ELISA Kit for Glutamate Decarboxylase 1, Brain (GAD1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC904Mu01 Recombinant Glutamate Decarboxylase 1, Brain (GAD1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC904Mu02 Recombinant Glutamate Decarboxylase 1, Brain (GAD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC904Mu01 Polyclonal Antibody to Glutamate Decarboxylase 1, Brain (GAD1) WB; IHC; ICC; IP.
LAC904Mu71 Biotin-Linked Polyclonal Antibody to Glutamate Decarboxylase 1, Brain (GAD1) WB; IHC; ICC.
PAC904Mu02 Polyclonal Antibody to Glutamate Decarboxylase 1, Brain (GAD1) WB; IHC; ICC; IP.
Assay Kits SEC904Mu ELISA Kit for Glutamate Decarboxylase 1, Brain (GAD1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC904Ra01 Recombinant Glutamate Decarboxylase 1, Brain (GAD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC904Ra01 Polyclonal Antibody to Glutamate Decarboxylase 1, Brain (GAD1) WB; IHC; ICC; IP.
LAC904Ra71 Biotin-Linked Polyclonal Antibody to Glutamate Decarboxylase 1, Brain (GAD1) WB; IHC; ICC.
Assay Kits SEC904Ra ELISA Kit for Glutamate Decarboxylase 1, Brain (GAD1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene."Proc. Natl. Acad. Sci. U.S.A. 89:2115-2119(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD."Genomics 21:222-228(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of large isoform of human brain glutamic acid decarboxylase."Lancet 338:1468-1469(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Nucleotide sequence and chromosomal assignment of a cDNA encoding the large isoform of human glutamate decarboxylase."Ann. Hum. Genet. 56:255-265(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning of full-length glutamic acid decarboxylase 67 from human pancreas and islets."Biochem. Biophys. Res. Commun. 192:1347-1352(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning and expression of large isoform of glutamic acid decarboxylase from human pancreatic islet."Biochem. Biophys. Res. Commun. 192:1353-1359(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues."J. Biol. Chem. 275:5188-5192(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Cloning and partial nucleotide sequence of human glutamic acid decarboxylase cDNA from brain and pancreatic islets."Biochem. Biophys. Res. Commun. 176:1239-1244(1991) [PubMed] [Europe PMC] [Abstract]
  11. "Expression of the neurotransmitter-synthesizing enzyme glutamic acid decarboxylase in male germ cells."Mol. Cell. Biol. 10:4701-4711(1990) [PubMed] [Europe PMC] [Abstract]
  12. "GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop."Nat. Struct. Mol. Biol. 14:280-286(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders."BMC Neurol. 4:20-20(2004) [PubMed] [Europe PMC] [Abstract]