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Sperm Associated Antigen 1 (SPAG1)

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HSD-3.8; SP75; TPIS

Sperm Associated Antigen 1 (SPAG1)
CCC C865
HGNC 11212
MGI 1349387
PubMed 24055112
RGD 1310702
UniProt Q07617
Wiki SPAG1
SPAG1 is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC865Hu01 Recombinant Sperm Associated Antigen 1 (SPAG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC865Hu01 Polyclonal Antibody to Sperm Associated Antigen 1 (SPAG1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Sperm Associated Antigen 1 (SPAG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sperm Associated Antigen 1 (SPAG1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sperm Associated Antigen 1 (SPAG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sperm Associated Antigen 1 (SPAG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sperm Associated Antigen 1 (SPAG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sperm Associated Antigen 1 (SPAG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sperm Associated Antigen 1 (SPAG1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sperm Associated Antigen 1 (SPAG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sperm Associated Antigen 1 (SPAG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sperm Associated Antigen 1 (SPAG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sperm Associated Antigen 1 (SPAG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sperm Associated Antigen 1 (SPAG1) ELISA Kit Customized Service Offer
  1. "Expression and function of the HSD-3.8 gene encoding a testis-specific protein."Mol. Hum. Reprod. 7:811-818(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation and sequencing of the cDNA encoding the 75-kD human sperm protein related to infertility."Chin. Med. J. 105:998-1003(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells."Oncogene 26:1533-1545(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms." Am. J. Hum. Genet. 93:711-720(2013) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]