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Small Nuclear Ribonucleoprotein Polypeptide B (SNRPB)

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SNRP-B; SNRPB1; COD; snRNP-B; Small nuclear ribonucleoprotein-associated proteins B and B'; Sm protein B/B'

Small Nuclear Ribonucleoprotein Polypeptide B (SNRPB)
CCC C861
HGNC 11153
MGI 98342
PubMed 10556313
UniProt P14678
Wiki SNRPB
Small nuclear ribonucleoprotein polypeptides B and B1 is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene.Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. N bears Sm epitopes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Nuclear Ribonucleoprotein Polypeptide B (SNRPB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Nuclear Ribonucleoprotein Polypeptide B (SNRPB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Nuclear Ribonucleoprotein Polypeptide B (SNRPB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Nuclear Ribonucleoprotein Polypeptide B (SNRPB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear Ribonucleoprotein Polypeptide B (SNRPB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Nuclear Ribonucleoprotein Polypeptide B (SNRPB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Nuclear Ribonucleoprotein Polypeptide B (SNRPB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Nuclear Ribonucleoprotein Polypeptide B (SNRPB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Nuclear Ribonucleoprotein Polypeptide B (SNRPB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear Ribonucleoprotein Polypeptide B (SNRPB) ELISA Kit Customized Service Offer
  1. "Cloned human snRNP proteins B and B' differ only in their carboxy-terminal part."EMBO J. 8:3853-3860(1989) [PubMed] [Europe PMC] [Abstract]
  2. "A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'."Nucleic Acids Res. 17:1733-1743(1989) [PubMed] [Europe PMC] [Abstract]
  3. ErratumNucleic Acids Res. 17:6777-6777(1989)
  4. "Molecular cloning of cDNA encoding Sm autoantigen: derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles."Proc. Natl. Acad. Sci. U.S.A. 86:4249-4253(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci."Nucleic Acids Res. 27:4577-4584(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction."J. Immunol. 145:636-643(1990) [PubMed] [Europe PMC] [Abstract]