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Synuclein Alpha Interacting Protein 1 (SNCaIP1)

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SYPH1; Sph1; Synphilin 1; Alpha-synuclein-interacting protein

Synuclein Alpha Interacting Protein 1 (SNCaIP1)
CCC C859
HGNC 11139
MGI 1915097
PubMed 11331421
RGD 1309283
UniProt Q9Y6H5
Wiki SNCAIP
Synphilin-1 is a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif.
The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. Widely expressed, with highest levels in brain, heart and placenta.
A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but their full-length nature has yet to be determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synuclein Alpha Interacting Protein 1 (SNCaIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synuclein Alpha Interacting Protein 1 (SNCaIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synuclein Alpha Interacting Protein 1 (SNCaIP1) Polyclonal Antibody Customized Service Offer
Assay Kits SEC859Hu ELISA Kit for Synuclein Alpha Interacting Protein 1 (SNCaIP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synuclein Alpha Interacting Protein 1 (SNCaIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synuclein Alpha Interacting Protein 1 (SNCaIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synuclein Alpha Interacting Protein 1 (SNCaIP1) Polyclonal Antibody Customized Service Offer
Assay Kits SEC859Mu ELISA Kit for Synuclein Alpha Interacting Protein 1 (SNCaIP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC859Ra01 Recombinant Synuclein Alpha Interacting Protein 1 (SNCaIP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC859Ra01 Polyclonal Antibody to Synuclein Alpha Interacting Protein 1 (SNCaIP1) WB; IHC
Assay Kits n/a CLIA Kit for Synuclein Alpha Interacting Protein 1 (SNCaIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synuclein Alpha Interacting Protein 1 (SNCaIP1) ELISA Kit Customized Service Offer
  1. "Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions."Nat. Genet. 22:110-114(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Organization of the human synphilin-1 gene, a candidate for Parkinson's disease."Mamm. Genome 11:763-766(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients."Proc. Natl. Acad. Sci. U.S.A. 103:5917-5922(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease."Nat. Med. 7:1144-1150(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1."J. Biol. Chem. 278:29106-29114(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Siah-1 facilitates ubiquitination and degradation of synphilin-1."J. Biol. Chem. 278:51504-51514(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease."Proc. Natl. Acad. Sci. U.S.A. 101:5500-5505(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation."J. Biol. Chem. 284:11706-11716(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication."FASEB J. 24:196-205(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease."Hum. Mol. Genet. 12:1223-1231(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Genetic association study of synphilin-1 in idiopathic Parkinson's disease."BMC Med. Genet. 9:19-19(2008) [PubMed] [Europe PMC] [Abstract]