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Tissue Specific Transplantation Antigen P35B (TSTA3)

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FX; P35B; SDR4E1; Short-chain dehydrogenase/reductase family 4E member 1; GDP-L-Fucose Synthase; GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase

Tissue Specific Transplantation Antigen P35B (TSTA3)
CCC C818
HGNC 12390
MGI 98857
PubMed 22528125
RGD 1307028
UniProt Q13630
Wiki TSTA3
Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose.
GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC818Hu01 Recombinant Tissue Specific Transplantation Antigen P35B (TSTA3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC818Hu01 Polyclonal Antibody to Tissue Specific Transplantation Antigen P35B (TSTA3) WB,IHC
Assay Kits n/a CLIA Kit for Tissue Specific Transplantation Antigen P35B (TSTA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tissue Specific Transplantation Antigen P35B (TSTA3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC818Mu01 Recombinant Tissue Specific Transplantation Antigen P35B (TSTA3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC818Mu01 Polyclonal Antibody to Tissue Specific Transplantation Antigen P35B (TSTA3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tissue Specific Transplantation Antigen P35B (TSTA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tissue Specific Transplantation Antigen P35B (TSTA3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tissue Specific Transplantation Antigen P35B (TSTA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tissue Specific Transplantation Antigen P35B (TSTA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tissue Specific Transplantation Antigen P35B (TSTA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tissue Specific Transplantation Antigen P35B (TSTA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tissue Specific Transplantation Antigen P35B (TSTA3) ELISA Kit Customized Service Offer
  1. "Synthesis of GDP-L-fucose by the human FX protein."J. Biol. Chem. 271:27274-27279(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum-transplantation antigen P35B."Blood 85:264-267(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "The crystal structure of human GDP-L-fucose synthase."Acta Biochim. Biophys. Sin. 45:720-725(2013) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of human GDP-L-fucose synthase with bound NADP."Submitted (APR-2013) to the PDB data bank