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Prosaposin (PSAP)

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SAP1; GLBA; CSAct; Dispersin; Pro-Saposin; Proactivator polypeptide; Glucosylceramidase activator; Sulfatide/GM1 activator; Cerebroside sulfate activator; Sphingolipid Activator 1

Prosaposin (PSAP)
CCC C756
HGNC 9498
MGI 97783
PubMed 15743835
RGD 3423
UniProt P07602
Wiki Prosaposin
Prosaposin also known as PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Saposin is an acronym for Sphingolipid Activator PrO[S]teINs. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities.Saposins A-D are required for the hydrolysis of certain shingolipids by specific lysosomal hydrolases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC756Hu01 Recombinant Prosaposin (PSAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC756Hu01 Polyclonal Antibody to Prosaposin (PSAP) WB,IHC,ICC/IF
MAC756Hu22 Monoclonal Antibody to Prosaposin (PSAP) WB; IHC; ICC; IP.
MAC756Hu21 Monoclonal Antibody to Prosaposin (PSAP) WB; IHC; ICC; IP.
MAC756Hu23 Monoclonal Antibody to Prosaposin (PSAP) WB; IHC; ICC; IP.
MAC756Hu24 Monoclonal Antibody to Prosaposin (PSAP) WB; IHC; ICC; IP.
Assay Kits SEC756Hu ELISA Kit for Prosaposin (PSAP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prosaposin (PSAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prosaposin (PSAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prosaposin (PSAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prosaposin (PSAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prosaposin (PSAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prosaposin (PSAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prosaposin (PSAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prosaposin (PSAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prosaposin (PSAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prosaposin (PSAP) ELISA Kit Customized Service Offer
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  23. "Structure of the asparagine-linked sugar chains of porcine kidney and human urine cerebroside sulfate activator protein."J. Mass Spectrom. 35:1416-1424(2000) [PubMed] [Europe PMC] [Abstract]
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  25. "The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin."EMBO J. 22:6430-6437(2003) [PubMed] [Europe PMC] [Abstract]
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  31. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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  39. "An Asn > Lys substitution in saposin B involving a conserved amino acidic residue and leading to the loss of the single N-glycosylation site in a patient with metachromatic leukodystrophy and normal arylsulphatase A activity."Eur. J. Hum. Genet. 7:125-130(1999) [PubMed] [Europe PMC] [Abstract]
  40. "A non-glycosylated and functionally deficient mutant (N215H) of the sphingolipid activator protein B (SAP-B) in a novel case of metachromatic leukodystrophy (MLD)."J. Inherit. Metab. Dis. 23:63-76(2000) [PubMed] [Europe PMC] [Abstract]
  41. "A novel mutation in the coding region of the prosaposin gene leads to a complete deficiency of prosaposin and saposins, and is associated with a complex sphingolipidosis dominated by lactosylceramide accumulation."Hum. Mol. Genet. 10:927-940(2001) [PubMed] [Europe PMC] [Abstract]
  42. "A mutation in the saposin A coding region of the prosaposin gene in an infant presenting as Krabbe disease: first report of saposin A deficiency in humans."Mol. Genet. Metab. 84:160-166(2005) [PubMed] [Europe PMC] [Abstract]
  43. "Non-neuronopathic Gaucher disease due to saposin C deficiency."Clin. Genet. 72:538-542(2007) [PubMed] [Europe PMC] [Abstract]