Peroxiredoxin 1 (PRDX1)

[Edit]

MSP23; NKEFA; PAG; PAGA; PAGB; TDPX2; Natural killer cell-enhancing factor A; Proliferation-associated; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2

Peroxiredoxin 1 (PRDX1)
Peroxiredoxin-1 is a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Three transcript variants encoding the same protein have been identified for this gene.Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC749Hu01 Recombinant Peroxiredoxin 1 (PRDX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC749Hu01 Polyclonal Antibody to Peroxiredoxin 1 (PRDX1) WB
MAC749Hu22 Monoclonal Antibody to Peroxiredoxin 1 (PRDX1) WB; IHC; ICC; IP.
LAC749Hu71 Biotin-Linked Polyclonal Antibody to Peroxiredoxin 1 (PRDX1) WB; IHC; ICC.
LAC749Hu81 FITC-Linked Polyclonal Antibody to Peroxiredoxin 1 (PRDX1) WB; IHC; ICC; IF.
Assay Kits SEC749Hu ELISA Kit for Peroxiredoxin 1 (PRDX1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC749Mu01 Recombinant Peroxiredoxin 1 (PRDX1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC749Mu02 Recombinant Peroxiredoxin 1 (PRDX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC749Mu01 Polyclonal Antibody to Peroxiredoxin 1 (PRDX1) WB; IHC; ICC; IP.
LAC749Mu81 FITC-Linked Polyclonal Antibody to Peroxiredoxin 1 (PRDX1) WB; IHC; ICC; IF.
LAC749Mu71 Biotin-Linked Polyclonal Antibody to Peroxiredoxin 1 (PRDX1) WB; IHC; ICC.
PAC749Mu02 Polyclonal Antibody to Peroxiredoxin 1 (PRDX1) WB; IHC; ICC; IP.
Assay Kits SEC749Mu ELISA Kit for Peroxiredoxin 1 (PRDX1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC749Ra01 Recombinant Peroxiredoxin 1 (PRDX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC749Ra01 Polyclonal Antibody to Peroxiredoxin 1 (PRDX1) WB; IHC; ICC; IP.
MAC749Ra21 Monoclonal Antibody to Peroxiredoxin 1 (PRDX1) WB; IHC; ICC; IP.
Assay Kits SEC749Ra ELISA Kit for Peroxiredoxin 1 (PRDX1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins."J. Biol. Chem. 268:11050-11056(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and sequence analysis of candidate human natural killer-enhancing factor genes."Immunogenetics 40:129-134(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (DEC-2008) to UniProtKB
  7. "A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress."Biochem. J. 366:777-785(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation."J. Biol. Chem. 277:25370-25376(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid."J. Biol. Chem. 277:38029-38036(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Regeneration of peroxiredoxins during recovery after oxidative stress: only some overoxidized peroxiredoxins can be reduced during recovery after oxidative stress."J. Biol. Chem. 278:37146-37153(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation."Science 300:653-656(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]