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Prostate Stem Cell Antigen (PSCA)

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Prostate Stem Cell Antigen (PSCA)
CCC C735
HGNC 9500
MGI 1919623
PubMed 10564591
UniProt O43653
Wiki PSCA
Prostate stem cell antigen is a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene has a nonsynonymous nucleotide polymorphism at its start codon.Highly expressed in prostate. Also found in bladder, placenta, stomach, colon and kidney. Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC735Hu01 Recombinant Prostate Stem Cell Antigen (PSCA) Positive Control; Immunogen; SDS-PAGE; WB.
RPC735Hu02 Recombinant Prostate Stem Cell Antigen (PSCA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC735Hu01 Polyclonal Antibody to Prostate Stem Cell Antigen (PSCA) WB; IHC; ICC; IP.
MAC735Hu22 Monoclonal Antibody to Prostate Stem Cell Antigen (PSCA) WB
PAC735Hu02 Polyclonal Antibody to Prostate Stem Cell Antigen (PSCA) WB; IHC; ICC; IP.
LAC735Hu71 Biotin-Linked Polyclonal Antibody to Prostate Stem Cell Antigen (PSCA) WB; IHC; ICC.
LAC735Hu72 Biotin-Linked Monoclonal Antibody to Prostate Stem Cell Antigen (PSCA) WB; IHC; ICC.
LAC735Hu82 FITC-Linked Monoclonal Antibody to Prostate Stem Cell Antigen (PSCA) WB; IHC; ICC; IF.
LAC735Hu81 FITC-Linked Polyclonal Antibody to Prostate Stem Cell Antigen (PSCA) WB; IHC; ICC; IF.
Assay Kits SEC735Hu ELISA Kit for Prostate Stem Cell Antigen (PSCA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostate Stem Cell Antigen (PSCA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostate Stem Cell Antigen (PSCA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostate Stem Cell Antigen (PSCA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostate Stem Cell Antigen (PSCA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostate Stem Cell Antigen (PSCA) ELISA Kit Customized Service Offer
  1. "Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer."Proc. Natl. Acad. Sci. U.S.A. 95:1735-1740(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumors."Biochem. Biophys. Res. Commun. 275:783-788(2000) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer."Oncogene 19:1288-1296(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer." Nat. Genet. 40:730-740(2008) [PubMed] [Europe PMC] [Abstract]