Organic Solute Transporter Beta (OSTb)


OST-B; OSTbeta; OST-beta; Solute carrier family 51 subunit beta

Organic Solute Transporter Beta (OSTb)
OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes. The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake. The heterodimer furthermore is essential for intestinal bile acid transport.
OST-alpha and OST-alpha have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.The deduced mouse and human OST-beta proteins contain 128 amino acids and share 63% amino acid identity. Real-time PCR showed high levels of both OST-alpha and OST-beta in human testis, colon, liver, small intestine, kidney, ovary, and adrenal gland, with lower levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland, and fat.

Organism species: Mus musculus (Mouse)

Proteins n/a Recombinant Organic Solute Transporter Beta (OSTb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Organic Solute Transporter Beta (OSTb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Organic Solute Transporter Beta (OSTb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Organic Solute Transporter Beta (OSTb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Organic Solute Transporter Beta (OSTb) ELISA Kit Customized Service Offer
  1. "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta."J. Biol. Chem. 278:27473-27482(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia."Hepatology 42:1270-1279(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes."Am. J. Physiol. 290:G476-G485(2006) [PubMed] [Europe PMC] [Abstract]
  5. "FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine."J. Lipid Res. 47:201-214(2006) [PubMed] [Europe PMC] [Abstract]