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Oxysterol Binding Protein (OSBP)

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OSBP1

Oxysterol Binding Protein (OSBP)
CCC C694
HGNC 8503
MGI 97447
PubMed 11238399
RGD 1308069
UniProt P22059
Wiki OSBP
Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase.
Oxysterol-binding proteins are evolutionary related proteins involved with sterol synthesis and/or its regulation. These include mammalian oxysterol-binding protein (OSBP), a protein of about 800 amino-acid residues that binds a variety of oxysterols (oxygenated derivatives of cholesterol); yeast OSH1, a protein of 859 residues that also plays a role in ergosterol synthesis; and yeast proteins HES1 and KES1, highly related proteins of 434 residues that seem to play a role in ergosterol synthesis

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC694Hu01 Recombinant Oxysterol Binding Protein (OSBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC694Hu01 Polyclonal Antibody to Oxysterol Binding Protein (OSBP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Oxysterol Binding Protein (OSBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oxysterol Binding Protein (OSBP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oxysterol Binding Protein (OSBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxysterol Binding Protein (OSBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxysterol Binding Protein (OSBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oxysterol Binding Protein (OSBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oxysterol Binding Protein (OSBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oxysterol Binding Protein (OSBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxysterol Binding Protein (OSBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxysterol Binding Protein (OSBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oxysterol Binding Protein (OSBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oxysterol Binding Protein (OSBP) ELISA Kit Customized Service Offer
  1. "cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19."Genomics 7:65-74(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina."J. Biol. Chem. 276:18570-18578(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation."Science 307:1472-1476(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "OSBP negatively regulates ABCA1 protein stability."J. Biol. Chem. 283:18210-18217(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies."J. Biol. Chem. 285:12961-12970(2010) [PubMed] [Europe PMC] [Abstract]
  17. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]