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Insulin Induced Gene 1 (INSIG1)

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CL6; INSIG-1 Membrane Protein

Insulin Induced Gene 1 (INSIG1)
CCC C544
HGNC 6083
MGI 1916289
PubMed 18989534
RGD 708457
UniProt O15503
Wiki Insig1
Insulin induced gene 1, also known as INSIG1, is a protein encoded by the INSIG1 gene.Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells.
This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC544Hu01 Recombinant Insulin Induced Gene 1 (INSIG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Insulin Induced Gene 1 (INSIG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Insulin Induced Gene 1 (INSIG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Insulin Induced Gene 1 (INSIG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Induced Gene 1 (INSIG1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Insulin Induced Gene 1 (INSIG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Insulin Induced Gene 1 (INSIG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Insulin Induced Gene 1 (INSIG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Insulin Induced Gene 1 (INSIG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Induced Gene 1 (INSIG1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Insulin Induced Gene 1 (INSIG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Insulin Induced Gene 1 (INSIG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Insulin Induced Gene 1 (INSIG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Insulin Induced Gene 1 (INSIG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Induced Gene 1 (INSIG1) ELISA Kit Customized Service Offer
  1. "Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene."Genomics 43:278-284(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER."Cell 110:489-500(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain."Mol. Cell 11:25-33(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Membrane topology of human insig-1, a protein regulator of lipid synthesis."J. Biol. Chem. 279:8487-8496(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase."Mol. Cell 19:829-840(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake."Cell Metab. 3:15-24(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis."Proc. Natl. Acad. Sci. U.S.A. 103:6154-6159(2006) [PubMed] [Europe PMC] [Abstract]
  11. "The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways."Mol. Cancer Res. 8:93-106(2010) [PubMed] [Europe PMC] [Abstract]