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Islet Cell Autoantigen 1 (ICA1)

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ICA69; ICAp69; ICA-p69; 69 kDa islet cell autoantigen

Islet Cell Autoantigen 1 (ICA1)
CCC C538
HGNC 5343
MGI 96391
PubMed 8162706
RGD 621465
UniProt Q05084
Wiki ICA1
Islet cell autoantigen 1, 69kDa, also known as ICA1 is a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules.
This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Islet Cell Autoantigen 1 expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC538Hu01 Recombinant Islet Cell Autoantigen 1 (ICA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC538Hu01 Polyclonal Antibody to Islet Cell Autoantigen 1 (ICA1) WB; IHC; ICC; IP.
LAC538Hu71 Biotin-Linked Polyclonal Antibody to Islet Cell Autoantigen 1 (ICA1) WB; IHC; ICC.
MAC538Hu21 Monoclonal Antibody to Islet Cell Autoantigen 1 (ICA1) WB
LAC538Hu72 Biotin-Linked Monoclonal Antibody to Islet Cell Autoantigen 1 (ICA1) WB; IHC; ICC.
Assay Kits SEC538Hu ELISA Kit for Islet Cell Autoantigen 1 (ICA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC538Mu01 Recombinant Islet Cell Autoantigen 1 (ICA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC538Mu01 Polyclonal Antibody to Islet Cell Autoantigen 1 (ICA1) WB; IHC; ICC; IP.
LAC538Mu71 Biotin-Linked Polyclonal Antibody to Islet Cell Autoantigen 1 (ICA1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Islet Cell Autoantigen 1 (ICA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Islet Cell Autoantigen 1 (ICA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Islet Cell Autoantigen 1 (ICA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Islet Cell Autoantigen 1 (ICA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Islet Cell Autoantigen 1 (ICA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Islet Cell Autoantigen 1 (ICA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Islet Cell Autoantigen 1 (ICA1) ELISA Kit Customized Service Offer
  1. "Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen."J. Clin. Invest. 92:359-371(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes."Biochim. Biophys. Acta 1227:101-104(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization and transcript analysis of ICAp69, a target antigen in diabetic autoimmunity."Genomics 38:382-391(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells."J. Biol. Chem. 278:26166-26173(2003) [PubMed] [Europe PMC] [Abstract]