≡

Huntingtin Interacting Protein 1 Related Protein (HIP1R)

[Edit]

HIP12; HIP3; ILWEQ; Huntingtin Interacting Protein 12

Huntingtin Interacting Protein 1 Related Protein (HIP1R)
CCC C525
HGNC 18415
MGI 1352504
PubMed 11063258
RGD 621615
UniProt O75146
Wiki HIP1R

Huntingtin Interacting Protein 1 is a membrane-associated protein that interacts with huntingtin (HTT), the protein altered in Huntington disease (HD). The highest degree of similarity occurs in the C-terminal region, which shows considerable homology to the cytoskeletal protein talin. HIP12 transcript in brain, heart, kidney, pancreas, and liver, but not in lung or placenta. In ES cell-derived neurons, both HIP1 and HIP12 are highly expressed and distributed throughout the cytoplasm and cell processes with enrichment within the cis-Golgi. In contrast to HIP1, which is toxic in cell culture, HIP12 does not confer toxicity in the same assay systems. HIP12 does not interact with huntingtin but can interact with HIP1, suggesting a potential interaction in vivo that may influence the function of each respective protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC525Hu01 Recombinant Huntingtin Interacting Protein 1 Related Protein (HIP1R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC525Hu01 Polyclonal Antibody to Huntingtin Interacting Protein 1 Related Protein (HIP1R) WB;ICC/IF
Assay Kits SEC525Hu ELISA Kit for Huntingtin Interacting Protein 1 Related Protein (HIP1R) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Huntingtin Interacting Protein 1 Related Protein (HIP1R) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Huntingtin Interacting Protein 1 Related Protein (HIP1R) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Huntingtin Interacting Protein 1 Related Protein (HIP1R) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Huntingtin Interacting Protein 1 Related Protein (HIP1R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Huntingtin Interacting Protein 1 Related Protein (HIP1R) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Huntingtin Interacting Protein 1 Related Protein (HIP1R) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Huntingtin Interacting Protein 1 Related Protein (HIP1R) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Huntingtin Interacting Protein 1 Related Protein (HIP1R) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Huntingtin Interacting Protein 1 Related Protein (HIP1R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Huntingtin Interacting Protein 1 Related Protein (HIP1R) ELISA Kit Customized Service Offer
  1. "HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin."Mamm. Genome 11:1006-1015(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1)."J. Hum. Genet. 43:268-271(1998) [PubMed] [Europe PMC] [Abstract]
  6. "HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain."J. Biol. Chem. 277:19897-19904(2002) [PubMed] [Europe PMC] [Abstract]
  7. "HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains."J. Biol. Chem. 279:14294-14306(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo."J. Biol. Chem. 280:6109-6117(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Structural definition of the F-actin-binding THATCH domain from HIP1R."Nat. Struct. Mol. Biol. 13:121-130(2006) [PubMed] [Europe PMC] [Abstract]