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Grancalcin (GCA)

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GCL; EF Hand Calcium Binding Protein

Grancalcin (GCA)
CCC C496
HGNC 15990
MGI 1918521
PubMed 12529388
RGD 1306589
UniProt P28676
Wiki GCA_(gene

Grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2.

Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC496Hu01 Recombinant Grancalcin (GCA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC496Hu01 Polyclonal Antibody to Grancalcin (GCA) WB; IHC
Assay Kits SEC496Hu ELISA Kit for Grancalcin (GCA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC496Mu01 Recombinant Grancalcin (GCA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC496Mu01 Polyclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IP.
Assay Kits SEC496Mu ELISA Kit for Grancalcin (GCA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Grancalcin (GCA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Grancalcin (GCA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Grancalcin (GCA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Grancalcin (GCA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Grancalcin (GCA) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes."J. Biol. Chem. 267:2928-2933(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils."Biochem. J. 286:549-554(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner."J. Biol. Chem. 276:17762-17769(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro."FEBS Lett. 545:151-154(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of human grancalcin, a member of the penta-EF-hand protein family."J. Mol. Biol. 300:1271-1281(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Structure of Ca(2+)-loaded human grancalcin."Acta Crystallogr. D 57:1843-1849(2001) [PubMed] [Europe PMC] [Abstract]