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Ferredoxin 1 (FDX1)

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ADX; FDX; LOH11CR1D; Adrenodoxin,Mitochondrial; Adrenal ferredoxin; Hepatoredoxin

Ferredoxin 1 (FDX1)
CCC C475
HGNC 3638
MGI 103224
PubMed 23435367
RGD 62036
UniProt P10109
Wiki FDX1
Adrenodoxin, mitochondrial is a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to a terminal cytochrome P450. This particular oxidation/reduction system is found in steroidogenic tissues, and is involved with the synthesis of bile acid and vitamin D.
In addition to the expressed gene at this chromosomal locus (11q22), there are pseudogenes located on chromosomes 20 and 21. This gene product has been identified in a number of different tissues but all forms have been shown to be identical and are not tissue specific.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ferredoxin 1 (FDX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ferredoxin 1 (FDX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ferredoxin 1 (FDX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ferredoxin 1 (FDX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ferredoxin 1 (FDX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC475Mu01 Recombinant Ferredoxin 1 (FDX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ferredoxin 1 (FDX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ferredoxin 1 (FDX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ferredoxin 1 (FDX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ferredoxin 1 (FDX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ferredoxin 1 (FDX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ferredoxin 1 (FDX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ferredoxin 1 (FDX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ferredoxin 1 (FDX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ferredoxin 1 (FDX1) ELISA Kit Customized Service Offer
  1. "Cloning and structure of the human adrenodoxin gene."DNA 7:609-615(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Human adrenodoxin: cloning of three cDNAs and cycloheximide enhancement in JEG-3 cells."J. Biol. Chem. 263:3240-3244(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and sequence analysis of human placental ferredoxin."Arch. Biochem. Biophys. 264:383-391(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Structure, sequence, chromosomal location, and evolution of the human ferredoxin gene family."DNA Cell Biol. 9:205-212(1990) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode."Bioelectrochemistry 59:41-47(2003) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis."Proc. Natl. Acad. Sci. U.S.A. 107:11775-11780(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "1H NMR spectra of vertebrate [2Fe-2S] ferredoxins. Hyperfine resonances suggest different electron delocalization patterns from plant ferredoxins."Biochemistry 30:9078-9083(1991) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of human ferredoxin-1 (FDX1) in complex with iron-sulfur cluster."Submitted (NOV-2010) to the PDB data bank
  13. "Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system."Proc. Natl. Acad. Sci. U.S.A. 108:10139-10143(2011) [PubMed] [Europe PMC] [Abstract]