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Fibulin 1 (FBLN1)

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Fibulin 1 (FBLN1)
CCC C472
HGNC 3600
MGI 95487
PubMed 11792823
RGD 1308667
UniProt P23142
Wiki Fibulin-1
Fibulin-1 is a secreted glycoprotein that is found in association with extracellular matrix structures including fibronectin-containing fibers, elastin-containing fibers and basement membranes. Fibulin-1 binds to a number of extracellular matrix constituents including fibronectin, nidogen-1, and the proteoglycan, versican. Fibulin-1 is also a blood protein capable of binding to fibrinogen.
Fibulin-1 has modular domain structure and includes a series of nine epidermal growth factor-like modules followed by a fibulin-type module, a module found in all members of the fibulin gene family.The human fibulin-1 gene, FBLN1, encodes four splice variants designated fibulin-1A, B, C and D, which differ in their carboxy terminal regions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC472Hu01 Recombinant Fibulin 1 (FBLN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC472Hu02 Recombinant Fibulin 1 (FBLN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC472Hu03 Recombinant Fibulin 1 (FBLN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC472Hu01 Polyclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC; IP.
MAC472Hu22 Monoclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC; IP.
LAC472Hu71 Biotin-Linked Polyclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC.
MAC472Hu21 Monoclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC; IP.
LAC472Hu72 Biotin-Linked Monoclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC.
PAC472Hu02 Polyclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC; IP.
PAC472Hu03 Polyclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC; IP.
Assay Kits SEC472Hu ELISA Kit for Fibulin 1 (FBLN1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC472Hu CLIA Kit for Fibulin 1 (FBLN1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC472Mu01 Recombinant Fibulin 1 (FBLN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC472Mu01 Polyclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC; IP.
LAC472Mu71 Biotin-Linked Polyclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC.
MAC472Mu21 Monoclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC; IP.
LAC472Mu72 Biotin-Linked Monoclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC.
Assay Kits SEC472Mu ELISA Kit for Fibulin 1 (FBLN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC472Ra01 Recombinant Fibulin 1 (FBLN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC472Ra02 Recombinant Fibulin 1 (FBLN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC472Ra01 Polyclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC; IP.
LAC472Ra71 Biotin-Linked Polyclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC.
PAC472Ra02 Polyclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC; IP.
MAC472Ra21 Monoclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC; IP.
LAC472Ra72 Biotin-Linked Monoclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC.
MAC472Ra22 Monoclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC; IP.
MAC472Ra23 Monoclonal Antibody to Fibulin 1 (FBLN1) WB; IHC; ICC; IP.
Assay Kits SEC472Ra ELISA Kit for Fibulin 1 (FBLN1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  12. "The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo."Histochem. J. 28:109-116(1996) [PubMed] [Europe PMC] [Abstract]
  13. "Estrogens increase the expression of fibulin-1, an extracellular matrix protein secreted by human ovarian cancer cells."Proc. Natl. Acad. Sci. U.S.A. 93:316-320(1996) [PubMed] [Europe PMC] [Abstract]
  14. "The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains."J. Biol. Chem. 272:22600-22606(1997) [PubMed] [Europe PMC] [Abstract]
  15. "Suppression of anchorage-independent growth and matrigel invasion and delayed tumor formation by elevated expression of fibulin-1D in human fibrosarcoma-derived cell lines."Oncogene 15:2159-2168(1997) [PubMed] [Europe PMC] [Abstract]
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  17. "Estradiol and fibulin-1 inhibit motility of human ovarian- and breast-cancer cells induced by fibronectin."Int. J. Cancer 75:654-658(1998) [PubMed] [Europe PMC] [Abstract]
  18. "The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling."Proc. Natl. Acad. Sci. U.S.A. 96:869-874(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Fibulin-1 suppression of fibronectin-regulated cell adhesion and motility."J. Cell Sci. 114:4587-4598(2001) [PubMed] [Europe PMC] [Abstract]
  20. "Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function."J. Neurochem. 76:1411-1420(2001) [PubMed] [Europe PMC] [Abstract]
  21. "Interaction of oncogenic papillomavirus E6 proteins with fibulin-1."Biochem. Biophys. Res. Commun. 296:962-969(2002) [PubMed] [Europe PMC] [Abstract]
  22. "The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly."J. Med. Genet. 39:98-104(2002) [PubMed] [Europe PMC] [Abstract]
  23. "Estrogen induction and overexpression of fibulin-1C mRNA in ovarian cancer cells."Oncogene 21:1097-1107(2002) [PubMed] [Europe PMC] [Abstract]
  24. "Elevated expression and altered processing of fibulin-1 protein in human breast cancer."Br. J. Cancer 88:871-878(2003) [PubMed] [Europe PMC] [Abstract]
  25. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  26. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  27. "Mutation of fibulin-1 causes a novel syndrome involving the central nervous system and connective tissues."Eur. J. Hum. Genet. 22:640-643(2014) [PubMed] [Europe PMC] [Abstract]