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Dual Oxidase 1 (DUOX1)

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LNOX1; NOXEF1; THOX1; NADPH Thyroid Oxidase 1; Flavoprotein NADPH Oxidase; Nicotinamide Adenine Dinucleotide Phosphate Oxidase

Dual Oxidase 1 (DUOX1)
CCC C443
HGNC 3062
MGI 2139422
PubMed 16111680
RGD 628760
UniProt Q9NRD9
Wiki Dual_oxidase_1

Dual oxidase 1 is an enzyme encoded by the DUOX1 gene. DUOX1 was first identified in the mammalian thyroid gland. In humans, two isoforms are found; hDUOX1 and hDUOX2. Human DUOX protein localization is not exclusive to thyroid tissue; hDUOX1 is prominent in airway epithelial cells and hDUOX2 in the salivary glands and gastrointestinal tract.Dual oxidases are characterized by a defining N-terminal, extracellular domain exhibiting considerable sequence identity with the mammalian peroxidases, a transmembrane (TM) segment appended to an EF-hand calcium-binding cytosolic region and a NOX2 homologous structure (six TMs tethered to NADPH oxidase). Topological studies place this peroxidase domain on the opposite side of the membrane from the NADPH oxidase domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Oxidase 1 (DUOX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Oxidase 1 (DUOX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Oxidase 1 (DUOX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Oxidase 1 (DUOX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Oxidase 1 (DUOX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Oxidase 1 (DUOX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Oxidase 1 (DUOX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Oxidase 1 (DUOX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Oxidase 1 (DUOX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Oxidase 1 (DUOX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Oxidase 1 (DUOX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Oxidase 1 (DUOX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Oxidase 1 (DUOX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Oxidase 1 (DUOX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Oxidase 1 (DUOX1) ELISA Kit Customized Service Offer
  1. "Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family."J. Biol. Chem. 275:23227-23233(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox."J. Cell Biol. 154:879-891(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system."Exp. Cell Res. 273:187-196(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense."FASEB J. 17:1502-1504(2003) [PubMed] [Europe PMC] [Abstract]
  8. "NADPH oxidase-dependent acid production in airway epithelial cells."J. Biol. Chem. 279:36454-36461(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium."FEBS Lett. 579:4911-4917(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of a novel partner of duox: EFP1, a thioredoxin-related protein."J. Biol. Chem. 280:3096-3103(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity."J. Biol. Chem. 280:30046-30054(2005) [PubMed] [Europe PMC] [Abstract]