≡

Death Associated Protein Kinase 1 (DAPK1)

[Edit]

Death Associated Protein Kinase 1 (DAPK1)
CCC C429
HGNC 2674
MGI 1916885
PubMed 17540169
RGD 1311629
UniProt P53355
Wiki DAPK1
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.In melanocytic cells DAPK1 gene expression may be regulated by MITF
DAP is expressed as a single 2.4-kb mRNA that codes for a basic proline-rich 15-kD protein. DAPK is transcribed into a single 6.3-kb mRNA encoded for a structurally unique 160-kD calmodulin-dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC429Hu01 Recombinant Death Associated Protein Kinase 1 (DAPK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC429Hu01 Polyclonal Antibody to Death Associated Protein Kinase 1 (DAPK1) WB; IHC; ICC; IP.
MAC429Hu22 Monoclonal Antibody to Death Associated Protein Kinase 1 (DAPK1) WB; IHC; ICC; IP.
Assay Kits SEC429Hu ELISA Kit for Death Associated Protein Kinase 1 (DAPK1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC429Mu01 Recombinant Death Associated Protein Kinase 1 (DAPK1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC429Mu02 Recombinant Death Associated Protein Kinase 1 (DAPK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC429Mu01 Polyclonal Antibody to Death Associated Protein Kinase 1 (DAPK1) WB; IHC; ICC; IP.
PAC429Mu02 Polyclonal Antibody to Death Associated Protein Kinase 1 (DAPK1) WB; IHC; ICC; IP.
Assay Kits SEC429Mu ELISA Kit for Death Associated Protein Kinase 1 (DAPK1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Death Associated Protein Kinase 1 (DAPK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Death Associated Protein Kinase 1 (DAPK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Death Associated Protein Kinase 1 (DAPK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Death Associated Protein Kinase 1 (DAPK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Death Associated Protein Kinase 1 (DAPK1) ELISA Kit Customized Service Offer
  1. "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death."Genes Dev. 9:15-30(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis."Mol. Cell. Biol. 20:1044-1054(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism."J. Biol. Chem. 276:47460-47467(2001) [PubMed] [Europe PMC] [Abstract]
  8. "DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death."J. Cell Biol. 157:455-468(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18."J. Biol. Chem. 278:26265-26274(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions."Mol. Cell. Biol. 24:8611-8626(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Programmed cell death 6 (PDCD6) protein interacts with death-associated protein kinase 1 (DAPk1): additive effect on apoptosis via caspase-3 dependent pathway."Biotechnol. Lett. 27:1011-1015(2005) [PubMed] [Europe PMC] [Abstract]
  12. "The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling."Curr. Biol. 15:1762-1767(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK."EMBO J. 24:294-304(2005) [PubMed] [Europe PMC] [Abstract]
  14. "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase."EMBO J. 24:1192-1201(2005) [PubMed] [Europe PMC] [Abstract]
  15. "The death-associated protein kinases: structure, function, and beyond."Annu. Rev. Biochem. 75:189-210(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Control of death-associated protein kinase (DAPK) activity by phosphorylation and proteasomal degradation."J. Biol. Chem. 281:39033-39040(2006) [PubMed] [Europe PMC] [Abstract]
  17. "DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress."Cell Death Differ. 14:1908-1915(2007) [PubMed] [Europe PMC] [Abstract]
  18. "DAP kinase mediates the phosphorylation of tropomyosin-1 downstream of the ERK pathway, which regulates the formation of stress fibers in response to oxidative stress."J. Cell Sci. 120:3666-3677(2007) [PubMed] [Europe PMC] [Abstract]
  19. "An alternative transcript from the death-associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing."FEBS J. 275:2574-2584(2008) [PubMed] [Europe PMC] [Abstract]
  20. "DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing."J. Biol. Chem. 283:9999-10014(2008) [PubMed] [Europe PMC] [Abstract]
  21. "DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression."Mol. Cell 32:371-382(2008) [PubMed] [Europe PMC] [Abstract]
  22. "DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy."EMBO Rep. 10:285-292(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling."J. Biol. Chem. 284:334-344(2009) [PubMed] [Europe PMC] [Abstract]
  24. "The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses."EMBO J. 29:1748-1761(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death."FEBS J. 277:48-57(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function."Mol. Cell 42:147-159(2011) [PubMed] [Europe PMC] [Abstract]
  27. "New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform."PLoS ONE 6:E17344-E17344(2011) [PubMed] [Europe PMC] [Abstract]
  28. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  29. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  30. "Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression."Nat. Struct. Biol. 8:899-907(2001) [PubMed] [Europe PMC] [Abstract]
  31. "An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury."Bioorg. Med. Chem. Lett. 13:3465-3470(2003) [PubMed] [Europe PMC] [Abstract]
  32. "Complex structure of kinase domain of DAP kinase with staurosporine."Submitted (APR-2006) to the PDB data bank
  33. "Recognition of human death-associated protein kinases by calmodulin."Submitted (JUL-2006) to the PDB data bank
  34. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]