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Heat Shock 70kDa Protein 5 (HSPA5)

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MIF2; BIP; GRP78; Immunoglobulin heavy chain-binding protein; Glucose Regulated Protein 78; Binding Immunoglobulin Protein; Endoplasmic reticulum lumenal Ca binding grp78

Heat Shock 70kDa Protein 5 (HSPA5)
CCC C343
HGNC 5238
MGI 95835
PubMed 17915553
RGD 2843
UniProt P11021
Wiki HSPA5

Binding immunoglobulin protein (BiP) is a molecular chaperone that uses ATP/ADP cycling to regulate protein folding by the protein disulfide isomerase (PDI) family of proteins. It is a 78kDa glucose-regulated heat shock protein and is involved in unfolded protein response. HSPA5 is its human gene. It binds to immunoglobulin heavy chain.

When the nucleotide-binding domain of GRP78 interacts with ATP, its substrate-binding domain can interact with unfolded/misfolded protein. Subsequent ATP hydrolysis acts to strengthen the interaction between GRP78 and the unfolded/misfolded protein. Under these conditions PDI can then work to promote disulfide oxidation and rearrangement until the correct protein conformation is achieved.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC343Hu01 Recombinant Heat Shock 70kDa Protein 5 (HSPA5) Positive Control; Immunogen; SDS-PAGE; WB.
RPC343Hu02 Recombinant Heat Shock 70kDa Protein 5 (HSPA5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC343Hu01 Polyclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5) WB; IHC; ICC; IP.
MAC343Hu22 Monoclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5) WB; IHC; ICC; IP.
Assay Kits SEC343Hu ELISA Kit for Heat Shock 70kDa Protein 5 (HSPA5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC343Mu01 Recombinant Heat Shock 70kDa Protein 5 (HSPA5) Positive Control; Immunogen; SDS-PAGE; WB.
RPC343Mu02 Recombinant Heat Shock 70kDa Protein 5 (HSPA5) Positive Control; Immunogen; SDS-PAGE; WB.
EPC343Mu61 Eukaryotic Heat Shock 70kDa Protein 5 (HSPA5) Positive Control; Immunogen; SDS-PAGE; WB.
RPC343Mu03 Recombinant Heat Shock 70kDa Protein 5 (HSPA5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC343Mu01 Polyclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5) WB; IHC; ICC; IP.
LAC343Mu71 Biotin-Linked Polyclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5) WB; IHC; ICC.
PAC343Mu02 Polyclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5) WB; IHC; ICC; IP.
MAC343Mu21 Monoclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5) WB; IHC; ICC; IP.
MAC343Mu22 Monoclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5) WB; IHC; ICC; IP.
MAC343Mu23 Monoclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5) WB; IHC; ICC; IP.
MAC343Mu24 Monoclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5) WB; IHC; ICC; IP.
MAC343Mu25 Monoclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5) WB; IHC; ICC; IP.
MAC343Mu27 Monoclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5) WB; IHC; ICC; IP.
Assay Kits SEC343Mu ELISA Kit for Heat Shock 70kDa Protein 5 (HSPA5) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC343Mu CLIA Kit for Heat Shock 70kDa Protein 5 (HSPA5) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC343Ra01 Recombinant Heat Shock 70kDa Protein 5 (HSPA5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC343Ra01 Polyclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5) WB; IHC; ICC; IP.
MAC343Ra21 Monoclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5) WB; IHC; ICC; IP.
Assay Kits SEC343Ra ELISA Kit for Heat Shock 70kDa Protein 5 (HSPA5) Enzyme-linked immunosorbent assay for Antigen Detection.
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