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Bcl2 Associated Athanogene 3 (BAG3)

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BIS; CAIR1; BAG Family Molecular Chaperone Regulator 3; Bcl-2-binding protein Bis; Docking protein CAIR-1

Bcl2 Associated Athanogene 3 (BAG3)
CCC C335
HGNC 939
MGI 1352493
PubMed 21472004
RGD 1307794
UniProt O95817
Wiki BAG3

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. BAG3 contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC335Hu01 Recombinant Bcl2 Associated Athanogene 3 (BAG3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC335Hu01 Polyclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) WB; IHC; ICC; IP.
MAC335Hu22 Monoclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) WB; IHC; ICC; IP.
Assay Kits SEC335Hu ELISA Kit for Bcl2 Associated Athanogene 3 (BAG3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bcl2 Associated Athanogene 3 (BAG3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bcl2 Associated Athanogene 3 (BAG3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bcl2 Associated Athanogene 3 (BAG3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bcl2 Associated Athanogene 3 (BAG3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bcl2 Associated Athanogene 3 (BAG3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bcl2 Associated Athanogene 3 (BAG3) ELISA Kit Customized Service Offer
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  14. "Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy." Nat. Genet. 44:450-455(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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  17. "Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy."Am. J. Hum. Genet. 88:273-282(2011) [PubMed] [Europe PMC] [Abstract]
  18. "BAG3-related myofibrillar myopathy in a Chinese family."Clin. Genet. 81:394-398(2012) [PubMed] [Europe PMC] [Abstract]
  19. "A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy." Eur. Heart J. 32:1065-1076(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes."Hum. Mutat. 32:1481-1491(2011) [PubMed] [Europe PMC] [Abstract]