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Aurora Kinase C (AURKC)

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AIE2; AIK3; AurC; STK13; ARK-3; Aurora-C; Serine/Threonine-Protein Kinase 13; Aurora/IPL1-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase aurora-C

Aurora Kinase C (AURKC)
CCC C308
HGNC 11391
MGI 1321119
PubMed 21733974
UniProt Q9UQB9
Wiki AURKC

Serine/threonine-protein kinase 13 is a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.mouse Aie1 (Aurora/Ipl1/EG2-1) and human STK13, which they designated AIE2. Both Aie1 and AIE2 contain a central serine/threonine kinase domain. The authors reported that AIE2 contains 309 amino acids. Northern blot analysis detected expression of a 1.35-kb AIE2 mRNA only in testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC308Hu01 Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC308Hu01 Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Aurora Kinase C (AURKC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aurora Kinase C (AURKC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC308Mu01 Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC308Mu01 Polyclonal Antibody to Aurora Kinase C (AURKC) WB,IHC
Assay Kits n/a CLIA Kit for Aurora Kinase C (AURKC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aurora Kinase C (AURKC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC308Ra01 Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
RPC308Ra02 Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC308Ra01 Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Aurora Kinase C (AURKC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aurora Kinase C (AURKC) ELISA Kit Customized Service Offer
  1. "Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators."DNA Cell Biol. 17:823-833(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter."Genomics 53:406-409(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Cell cycle-dependent expression and centrosome localization of a third human Aurora/Ipl1-related protein kinase, AIK3."J. Biol. Chem. 274:7334-7340(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and characterization of a novel human Aurora C splicing variant."Biochem. Biophys. Res. Commun. 328:353-361(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells."Cell Motil. Cytoskeleton 59:249-263(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C."J. Biol. Chem. 279:47201-47211(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Aurora C is directly associated with Survivin and required for cytokinesis."Genes Cells 10:617-626(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility."Nat. Genet. 39:661-665(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein."Biochem. Biophys. Res. Commun. 408:647-653(2011) [PubMed] [Europe PMC] [Abstract]
  12. "A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development."Hum. Reprod. 26:1868-1881(2011) [PubMed] [Europe PMC] [Abstract]
  13. "A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis."Mol. Hum. Reprod. 17:762-768(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]