Angiotensin II Receptor Associated Protein (AGTRAP)
[Edit]ATRAP; Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein
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Type-1 angiotensin II receptor-associated protein is a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
AGTRAP appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Angiotensin II Receptor Associated Protein (AGTRAP) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Angiotensin II Receptor Associated Protein (AGTRAP) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Angiotensin II Receptor Associated Protein (AGTRAP) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Angiotensin II Receptor Associated Protein (AGTRAP) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Angiotensin II Receptor Associated Protein (AGTRAP) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC286Mu01 | Recombinant Angiotensin II Receptor Associated Protein (AGTRAP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Angiotensin II Receptor Associated Protein (AGTRAP) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Angiotensin II Receptor Associated Protein (AGTRAP) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Angiotensin II Receptor Associated Protein (AGTRAP) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Angiotensin II Receptor Associated Protein (AGTRAP) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Angiotensin II Receptor Associated Protein (AGTRAP) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Angiotensin II Receptor Associated Protein (AGTRAP) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Angiotensin II Receptor Associated Protein (AGTRAP) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEC286Ra | ELISA Kit for Angiotensin II Receptor Associated Protein (AGTRAP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Identification and characterization of AGTRAP, a human homolog of murine angiotensin II receptor-associated protein (Agtrap)."Int. J. Biochem. Cell Biol. 34:93-102(2002) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling."Mol. Biol. Cell 14:5038-5050(2003) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]