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Alpha-1,4-Galactosyltransferase (a4GALT)

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A4GALT; P1; A14GALT; A4GALT1; PK; Lactosylceramide 4-Alpha-Galactosyltransferase; Globotriaosylceramide Synthase; Gb3 synthase; P1/Pk synthase; CD77 Synthase

Alpha-1,4-Galactosyltransferase (a4GALT)
CCC C274
HGNC 18149
MGI 3512453
PubMed 20971946
RGD 621583
UniProt Q9NPC4
Wiki A4GALT

Lactosylceramide 4-alpha-galactosyltransferase is an enzyme catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.

The A4GALT gene encodes alpha-1,4-galactosyltransferase, an enzyme that transfers a galactose to the alpha-1,4 position of lactosylceramide to form globotriaosylceramide (GB3), also known as CD77. This glycolipid has been characterized on red blood cells as the P(k) antigen of the P blood group system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC274Hu01 Recombinant Alpha-1,4-Galactosyltransferase (a4GALT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC274Hu01 Polyclonal Antibody to Alpha-1,4-Galactosyltransferase (a4GALT) WB; IHC
Assay Kits SEC274Hu ELISA Kit for Alpha-1,4-Galactosyltransferase (a4GALT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC274Mu01 Recombinant Alpha-1,4-Galactosyltransferase (a4GALT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC274Mu01 Polyclonal Antibody to Alpha-1,4-Galactosyltransferase (a4GALT) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-1,4-Galactosyltransferase (a4GALT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-1,4-Galactosyltransferase (a4GALT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC274Ra01 Recombinant Alpha-1,4-Galactosyltransferase (a4GALT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC274Ra01 Polyclonal Antibody to Alpha-1,4-Galactosyltransferase (a4GALT) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-1,4-Galactosyltransferase (a4GALT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-1,4-Galactosyltransferase (a4GALT) ELISA Kit Customized Service Offer
  1. "Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids."J. Biol. Chem. 275:15152-15156(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of the histo-blood group Pk UDP-galactose:Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase. Molecular genetic basis of the p phenotype."J. Biol. Chem. 275:16723-16729(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Human-specific amino acid changes found in 103 protein-coding genes."Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular basis for the p phenotype. Identification of distinct and multiple mutations in the alpha 1,4-galactosyltransferase gene in Swedish and Japanese individuals."J. Biol. Chem. 275:37752-37756(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Three-base deletion and one-base insertion of the alpha(1,4)galactosyltransferase gene responsible for the P phenotype."Transfusion 42:48-51(2002) [PubMed] [Europe PMC] [Abstract]