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Tight Junction Protein 1 (TJP1)

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ZO1; Zona Occludens 1; Zona occludens protein 1; Zonula occludens protein 1

Tight Junction Protein 1 (TJP1)
CCC C262
HGNC 11827
MGI 98759
PubMed 8825647
RGD 1306305
UniProt Q07157
Wiki TJP1

Tight junction protein ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene. Tight junction (zonula occludens) protein-1 (TJP1), also referred to as ZO-1, is a 200-kD protein located on a cytoplasmic membrane surface of vertebrate intercellular tight junctions. Willott et al. (1993) isolated a full-length cDNA sequence for human TJP1. Although the function of TJP1 is unknown, the cDNA sequence predicted a multi-domain signaling protein homologous to the product of the 'discs large-1' tumor suppressor gene of Drosophila  and several other membrane-associated proteins in mammals.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC262Hu01 Recombinant Tight Junction Protein 1 (TJP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC262Hu01 Polyclonal Antibody to Tight Junction Protein 1 (TJP1) WB; IHC; ICC; IP.
MAC262Hu22 Monoclonal Antibody to Tight Junction Protein 1 (TJP1) WB; IHC; ICC; IP.
Assay Kits SEC262Hu ELISA Kit for Tight Junction Protein 1 (TJP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tight Junction Protein 1 (TJP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tight Junction Protein 1 (TJP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tight Junction Protein 1 (TJP1) Polyclonal Antibody Customized Service Offer
Assay Kits SEC262Mu ELISA Kit for Tight Junction Protein 1 (TJP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC262Ra01 Recombinant Tight Junction Protein 1 (TJP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC262Ra01 Polyclonal Antibody to Tight Junction Protein 1 (TJP1) WB; IHC; ICC; IP.
MAC262Ra21 Monoclonal Antibody to Tight Junction Protein 1 (TJP1) WB; IHC; ICC; IP.
Assay Kits SEC262Ra ELISA Kit for Tight Junction Protein 1 (TJP1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions."Proc. Natl. Acad. Sci. U.S.A. 90:7834-7838(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
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  5. "The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction."Proc. Natl. Acad. Sci. U.S.A. 98:15191-15196(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Evidence for a functional interaction between cingulin and ZO-1 in cultured cells."J. Biol. Chem. 277:27757-27764(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular cloning, functional expression, and tissue distribution of a novel human gap junction-forming protein, connexin-31.9. Interaction with zona occludens protein-1."J. Biol. Chem. 277:38272-38283(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain."Neuroscience 126:611-630(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos)."Biol. Cell 101:319-334(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells."J. Biol. Chem. 284:14997-15006(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo."Circ. Res. 106:880-890(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Multi-tasking role of the mechanosensing protein Ankrd2 in the signaling network of striated muscle."PLoS ONE 6:E25519-E25519(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Comparative structural analysis of the erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity."J. Biol. Chem. 281:22312-22320(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Domain swapping within PDZ2 is responsible for dimerization of ZO proteins."J. Biol. Chem. 282:37710-37716(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites."EMBO J. 27:2113-2123(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3-guanylate kinase module."J. Biol. Chem. 285:13907-13917(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration."EMBO J. 30:665-678(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Solution structure of the second PDZ domain of Zonula Occludens 1."Proteins 79:1342-1346(2011) [PubMed] [Europe PMC] [Abstract]