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Actinin Alpha 1 (ACTN1)

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Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1

Actinin Alpha 1 (ACTN1)
CCC C236
HGNC 163
MGI 2137706
PubMed 23434115
RGD 70907
UniProt P12814
Wiki ACTN1

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.

Alpha-actinin-1 is a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC236Hu01 Recombinant Actinin Alpha 1 (ACTN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC236Hu02 Recombinant Actinin Alpha 1 (ACTN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC236Hu01 Polyclonal Antibody to Actinin Alpha 1 (ACTN1) WB; IHC; ICC; IP.
Assay Kits SEC236Hu ELISA Kit for Actinin Alpha 1 (ACTN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actinin Alpha 1 (ACTN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Actinin Alpha 1 (ACTN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actinin Alpha 1 (ACTN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actinin Alpha 1 (ACTN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actinin Alpha 1 (ACTN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC236Ra01 Recombinant Actinin Alpha 1 (ACTN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Actinin Alpha 1 (ACTN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actinin Alpha 1 (ACTN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actinin Alpha 1 (ACTN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actinin Alpha 1 (ACTN1) ELISA Kit Customized Service Offer
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  10. "Identification of the cytoskeletal protein alpha-actinin as a platelet thrombospondin-binding protein."FEBS Lett. 364:109-114(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy."Hum. Mol. Genet. 8:1329-1336(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins."Proc. Natl. Acad. Sci. U.S.A. 97:14632-14637(2000) [PubMed] [Europe PMC] [Abstract]
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  14. "The lipoma preferred partner LPP interacts with alpha-actinin."J. Cell Sci. 116:1359-1366(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring."J. Neurochem. 96:1659-1666(2006) [PubMed] [Europe PMC] [Abstract]
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  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Crystal structure of the actin-binding domain of alpha-actinin 1: evaluating two competing actin-binding models."J. Struct. Biol. 155:230-238(2006) [PubMed] [Europe PMC] [Abstract]
  21. "ACTN1 mutations cause congenital macrothrombocytopenia."Am. J. Hum. Genet. 92:431-438(2013) [PubMed] [Europe PMC] [Abstract]
  22. "A missense mutation in the alpha-actinin 1 gene (ACTN1) is the cause of autosomal dominant macrothrombocytopenia in a large French family."PLoS ONE 8:E74728-E74728(2013) [PubMed] [Europe PMC] [Abstract]